Salinomycin, Ready Made Solution

from Streptomyces albus, ≥98% (HPLC)

Antibiotic 61477, Coxxistac
Empirical Formula (Hill Notation):
Molecular Weight:
MDL number:
PubChem Substance ID:

Quality Level

biological source

Streptomyces albus


≥98% (HPLC)


2 mg/ml


DMSO: soluble
H2O: insoluble
alcohols: soluble
carbon tetrachloride: soluble
chloroform: soluble
ethers and esters: soluble
hexane: soluble

Mode of action

cell membrane | interferes

antibiotic activity spectrum


shipped in

dry ice

storage temp.


SMILES string




InChI key


Related Categories

General description

Chemical structure: polyether


Salinomycin, Ready Made Solution has been used as an inhibitor of endocytosis in primary pancreatic tumor cells. It has also been used in sequential treatment of cancer cells to study resistance.

Biochem/physiol Actions

Salinomycin is a monocarboxylic polyether antibiotic with unique tricyclic spiroketal ring systems and an unsaturated six-membered ring in the molecule. Salinomycin has antimicrobial and anticoccidial activities. It is an alkali ion carrier with affinity for cations and preference for K+ over other monovalent and divalent cations. Polyether antibiotics (also called carboxylic ionophores) facilitate bidirectional ion flux through the lipid barrier of membranes causing interference with natural ion transport systems both in prokaryotic and eukaryotic cells. Tumor cells express elevated levels of various types of K+ channels, which enhances cell proliferation. Thus, drugs acting as channel blockers inhibit cell proliferation. Being a highly selective potassium ionophore, salinomycin may interfere with potassium channels function in cancer stem cells (CSCs). Established cancer therapies may fail because they kill the bulk tumor cells, but do not eliminate CSCs. Studies indicate that Salinomycin selectively eradicates breast CSCs. Salinomycin may eliminate CSCs by inducing their differentiation. salinomycin suppresses the metastatic migration of 4T1 cells to the lungs.

Physical form

The product is supplied as a 2 mg/mL (2.66 mM) solution in DMSO, 0.2 μm-filtered.


NA 1993 / PGIII

WGK Germany


Flash Point(F)

188.6 °F - closed cup

Flash Point(C)

87 °C - closed cup

Certificate of Analysis

Certificate of Origin

Hartmut Beug
Cell, 138(4), 623-625 (2009-08-26)
During metastasis, migrating breast cancer stem cells undergo a loss of polarity leading to an epithelial-to-mesenchymal transition (EMT). Gupta et al. (2009) use this attribute of cancer stem cells to develop a high-throughput screen, which successfully identifies small molecules that...
Piyush B Gupta et al.
Cell, 138(4), 645-659 (2009-08-18)
Screens for agents that specifically kill epithelial cancer stem cells (CSCs) have not been possible due to the rarity of these cells within tumor cell populations and their relative instability in culture. We describe here an approach to screening for...
Dominik Fuchs et al.
Biochemical and biophysical research communications, 390(3), 743-749 (2009-10-20)
Salinomycin is a polyether antibiotic isolated from Streptomyces albus that acts in different biological membranes as a ionophore with a preference for potassium. It is widely used as an anticoccidial drug in poultry and is fed to ruminants to improve...
Salinomycin: a new monovalent cation ionophore.
M Mitani et al.
Biochemical and biophysical research communications, 66(4), 1231-1236 (1975-10-27)
Qiao Ming Zhi et al.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 65(7), 509-515 (2011-10-15)
Salinomycin is a novel identified cancer stem cells (CSCs) killer. Higher ALDH activity represents CSCs characterization. Here, we screened ALDH activities on several gastric cancer cell lines and divided them into ALDH(high) and ALDH(low) gastric cancer groups. ALDH(high) cancer cells...

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