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S6319

Sigma-Aldrich

Sertraline hydrochloride

≥98% (HPLC)

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Synonym(s):
Sertraline HCl, (1S,4S)-4-(3,4-Dichlorophenyl)-1,2,3,4-tetrahydro-N-methyl-1-naphthalenamine hydrochloride
Empirical Formula (Hill Notation):
C17H17NCl2 · HCl
CAS Number:
Molecular Weight:
342.69
MDL number:
PubChem Substance ID:
NACRES:
NA.77

Quality Level

Assay

≥98% (HPLC)

form

powder

optical activity

[α]/D +33 to +43°, c = 2.0 in methanol

storage condition

desiccated

color

white

solubility

DMSO: >20 mg/mL

SMILES string

ClC1=C(Cl)C=CC([C@H]2C3=C(C=CC=C3)[C@@H](NC)CC2)=C1.[H]Cl

InChI

1S/C17H17Cl2N.ClH/c1-20-17-9-7-12(13-4-2-3-5-14(13)17)11-6-8-15(18)16(19)10-11;/h2-6,8,10,12,17,20H,7,9H2,1H3;1H/t12-,17-;/m0./s1

InChI key

BLFQGGGGFNSJKA-XHXSRVRCSA-N

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This Item
PHR2535Y00008285.06188
Sertraline hydrochloride Pharmaceutical Secondary Standard; Certified Reference Material

Supelco

PHR2535

Sertraline hydrochloride

Sertraline hydrochloride European Pharmacopoeia (EP) Reference Standard

Y0000828

Sertraline hydrochloride

form

powder

form

powder

form

-

form

solid

storage condition

desiccated

storage condition

-

storage condition

-

storage condition

OK to freeze, protect from light

color

white

color

-

color

-

color

white

solubility

DMSO: >20 mg/mL

solubility

-

solubility

-

solubility

DMSO: 100 mM, ethanol: 50 mM

optical activity

[α]/D +33 to +43°, c = 2.0 in methanol

optical activity

-

optical activity

-

optical activity

-

Application

The effect of exposure of sertraline hydrochloride was studied in chronically prepared ovine fetus. It was used in glucocorticoid function assay to study the effect of antidepressants on glucocorticoid receptor function in humans.

Biochem/physiol Actions

Sertraline suppresses platelet function and exhibits antiplatelet and endothelium protective functions. It relieves depression and improves the quality of life in patients with cardiovascular disorders. It can also be prescribed to treat depression in Parkinson′s disease.
Selective serotonin reuptake inhibitor, antidepressant.

Features and Benefits

This compound is a featured product for ADME Tox research. Click here to discover more featured ADME Tox products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound is featured on the Biogenic Amine Transporters page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Signal Word

Warning

Hazard Statements

Hazard Classifications

Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - STOT RE 2

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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