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S7067

Sigma-Aldrich

SB 202190

≥98% (HPLC)

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Synonym(s):
4-(4-Fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)-1H-imidazole
Empirical Formula (Hill Notation):
C20H14FN3O
CAS Number:
Molecular Weight:
331.34
MDL number:
PubChem Substance ID:
NACRES:
NA.77

Quality Level

assay

≥98% (HPLC)

form

powder

color

faintly yellow, to beige

solubility

DMSO: 10 mg/mL, clear

originator

GlaxoSmithKline

storage temp.

2-8°C

SMILES string

Oc1ccc(cc1)-c2nc(-c3ccc(F)cc3)c([nH]2)-c4ccncc4

InChI

1S/C20H14FN3O/c21-16-5-1-13(2-6-16)18-19(14-9-11-22-12-10-14)24-20(23-18)15-3-7-17(25)8-4-15/h1-12,25H,(H,23,24)

InChI key

QHKYPYXTTXKZST-UHFFFAOYSA-N

Gene Information

human ... MAPK14(1432)

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SB 202190 ≥98% (HPLC)

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SB 202190 SB 202190, CAS 152121-30-7, is a potent, reversible, competitive inhibitor of p38. Inhibits p38 phosphorylation of myelin basic protein. Blocks the activity of p38β (Ki = 16 nM; IC₅₀ = 350 nM).

559388

SB 202190

SD-208 ≥98% (HPLC), powder

S7071

SD-208

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

storage temp.

2-8°C

storage temp.

−20°C

storage temp.

−20°C

storage temp.

2-8°C

solubility

DMSO: 10 mg/mL, clear

solubility

DMSO: ≥20 mg/mL

solubility

DMSO: 50 mg/mL

solubility

DMSO: >5 mg/mL

originator

GlaxoSmithKline

originator

-

originator

-

originator

-

General description

SB202190 aids in enhancing the self-renewal ability of neural stem cells fromNPC1-deficient mice.

Application

SB 202190 has been used:
  • to investigate the role of p38mitogen-activated protein kinase (MAPK) signaling in establishment of reovirus infection
  • as a p38α inhibitor in in vivo studies to study its impact on the development or progression of adenocarcinoma in the colon mucosa tissues of APC Min/+ mice.
  • as a component of basic BC medium to culture basal progenitor cells.
  • as a component of normal endometrium and endometrial tumor media for organoid culture.
SB 202190 was used to inhibit p38 activation in MCF7 cells5, mouse macrophages6 and HepG2 cells.7

Biochem/physiol Actions

SB 202190 is a highly selective, potent and cell permeable inhibitor of p38 MAP kinase. SB 202190 binds within the ATP pocket of the active kinase (Kd = 38 nM, as measured in recombinant human p38), and selectively inhibits the p38α and β isoforms.

Features and Benefits

This compound is featured on the MAPKs page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by GlaxoSmithKline. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Legal Information

Sold for research purposes under agreement from Glaxo­Smith­Kline

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

ppe

dust mask type N95 (US), Eyeshields, Gloves


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Protocol for generating airway organoids from 2D air liquid interface-differentiated nasal epithelia for use in a functional CFTR assay
Rodenburg LW, et al.
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NPC1 gene deficiency leads to lack of neural stem cell self-renewal and abnormal differentiation through activation of p38 mitogen-activated protein kinase signaling
Yang SR, et al.
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Uncoupling p38? nuclear and cytoplasmic functions and identification of two p38? phosphorylation sites on ?-catenin: implications for the Wnt signaling pathway in CRC models
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p38 Mitogen-Activated Protein Kinase Signaling Enhances Reovirus Replication by Facilitating Efficient Virus Entry, Capsid Uncoating, and Postuncoating Steps
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