The protocol for 3dGRO® Gastrointestinal Organoids SCC310-SCC370 describes reconstituting this product to 20 mM in DMSO, followed by filter sterilization of the 2X Intestinal Media Supplement using a 0.2 μm filter:
S7067
SB 202190
≥98% (HPLC), powder, p38 MAP kinase inhibitor
Synonym(s):
4-(4-Fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)-1H-imidazole
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5 MG
$153.00
25 MG
$590.00
About This Item
Empirical Formula (Hill Notation):
C20H14FN3O
CAS Number:
Molecular Weight:
331.34
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
MDL number:
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Product Name
SB 202190, ≥98% (HPLC)
SMILES string
Oc1ccc(cc1)-c2nc(-c3ccc(F)cc3)c([nH]2)-c4ccncc4
InChI key
QHKYPYXTTXKZST-UHFFFAOYSA-N
InChI
1S/C20H14FN3O/c21-16-5-1-13(2-6-16)18-19(14-9-11-22-12-10-14)24-20(23-18)15-3-7-17(25)8-4-15/h1-12,25H,(H,23,24)
assay
≥98% (HPLC)
form
powder
color
faintly yellow, to beige
solubility
DMSO: 10 mg/mL, clear
originator
GlaxoSmithKline
storage temp.
2-8°C
Quality Level
Gene Information
human ... MAPK14(1432)
Related Categories
1 of 4
This Item | S8307 | 559388 | S7071 |
|---|---|---|---|
| assay ≥98% (HPLC) | assay ≥98% (HPLC) | assay ≥98% (HPLC) | assay ≥98% (HPLC) |
| form powder | form solid | form solid | form powder |
| Quality Level 100 | Quality Level 100 | Quality Level 100 | Quality Level 100 |
| storage temp. 2-8°C | storage temp. −20°C | storage temp. −20°C | storage temp. 2-8°C |
| solubility DMSO: 10 mg/mL, clear | solubility DMSO: ≥20 mg/mL | solubility DMSO: 50 mg/mL | solubility DMSO: >5 mg/mL |
| originator GlaxoSmithKline | originator - | originator - | originator - |
Application
SB 202190 has been used:
- to investigate the role of p38mitogen-activated protein kinase (MAPK) signaling in establishment of reovirus infection[1]
- as a p38α inhibitor in in vivo studies to study its impact on the development or progression of adenocarcinoma in the colon mucosa tissues of APC Min/+ mice.[2]
- as a component of basic BC medium to culture basal progenitor cells.[3]
- as a component of normal endometrium and endometrial tumor media for organoid culture.[4]
SB 202190 was used to inhibit p38 activation in MCF7 cells5, mouse macrophages6 and HepG2 cells.7
Biochem/physiol Actions
SB 202190 is a highly selective, potent and cell permeable inhibitor of p38 MAP kinase. SB 202190 binds within the ATP pocket of the active kinase (Kd = 38 nM, as measured in recombinant human p38), and selectively inhibits the p38α and β isoforms.
Features and Benefits
This compound is featured on the MAPKs page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by GlaxoSmithKline. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
General description
SB202190 aids in enhancing the self-renewal ability of neural stem cells fromNPC1-deficient mice.[5]
Legal Information
Sold for research purposes under agreement from GlaxoSmithKline
Storage Class
11 - Combustible Solids
wgk
WGK 3
ppe
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NPC1 gene deficiency leads to lack of neural stem cell self-renewal and abnormal differentiation through activation of p38 mitogen-activated protein kinase signaling
Yang SR, et al.
Journal of Separation Science, 24(2), 292-298 (2006)
Protocol for generating airway organoids from 2D air liquid interface-differentiated nasal epithelia for use in a functional CFTR assay
Rodenburg LW, et al.
STAR protocols, 4(3), 102337-102337 (2023)
Edward Thorp et al.
The Journal of biological chemistry, 286(38), 33335-33344 (2011-08-11)
Mer tyrosine kinase (MerTK) is an integral membrane protein that is preferentially expressed by phagocytic cells, where it promotes efferocytosis and inhibits inflammatory signaling. Proteolytic cleavage of MerTK at an unidentified site leads to shedding of its soluble ectodomain (soluble
Shauna M Crowley et al.
PLoS pathogens, 16(4), e1008498-e1008498 (2020-04-14)
We investigated the role of the inflammasome effector caspases-1 and -11 during Salmonella enterica serovar Typhimurium infection of murine intestinal epithelial cells (IECs). Salmonella burdens were significantly greater in the intestines of caspase-1/11 deficient (Casp1/11-/-), Casp1-/- and Casp11-/- mice, as
Uncoupling p38? nuclear and cytoplasmic functions and identification of two p38? phosphorylation sites on ?-catenin: implications for the Wnt signaling pathway in CRC models
Lepore Signorile M, et al.
Journal of Separation Science, 13(1), 223-223 (2023)
Related Content
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Hello, we plan to use this product for organoid culture. Could you please confirm if it needs to be filtered with a 0.22 µm filter after reconstitution? Best regards, Jihye
1 answer-
Helpful?
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此试剂配制为溶液后储存温度是多少，可以储存多久？
1 answer-
When reconstituted in DMSO at 10 mg/mL, stock solutions are stable for up to 6 months when stored in aliquots at -20°C. Avoid repeated freeze/thaw cycles.
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