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Span® 85

Sorbitane trioleate
CAS Number:
EC Number:
MDL number:
PubChem Substance ID:

Quality Level



mol wt

957.52 g/mol


chloroform: 50 mg/mL, clear, faintly to light yellow



SMILES string




InChI key


General description

Sorbitane trioleate, or Span 85, is a non-ionic detergent.


Sorbitane trioleate, or Span 85, has been used in a study to develop a novel bottom-up process to produce nanoparticles containing protein and peptide for suspension in hydrofluoroalkane propellants. It has also been used in a study to analyze the application of liquid chromatography in polymer non-ionic antistatic additives.


250 mL in poly bottle
1 L in poly bottle

Other Notes

Fatty acid composition: Oleic acid (C18:1) ≥ 60%; linoleic acid (C18:2) 3 - 12%; linolenic acid (C18:2) ≤ 3%; palmitoleic acid (C16:1) 2 - 6%; balance primarily palmitic acid (C16:0).

Legal Information

Span is a registered trademark of Croda International PLC

Storage Class Code

10 - Combustible liquids



Flash Point(F)

437.0 °F

Flash Point(C)

225 °C

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificate of Analysis

Certificate of Origin

F O Opawale et al.
The Journal of pharmacy and pharmacology, 50(9), 965-973 (1998-11-12)
The purpose of this study was to investigate the influence of mixtures of the emulsifiers Span 80, 83 and 85 and Tween 80 on multiple emulsion stability. An oscillatory ring-surface rheometer was used to measure interfacial elasticity at the oil-aqueous
R N Dalby et al.
Pharmaceutical research, 5(1), 36-39 (1988-01-01)
The delivery of particles as small as possible (preferably less than 5 microns) to the respiratory tract should be the aim of those formulating metered dose inhalers (MDIs). This may be facilitated by the formulation of solution, rather than suspension-type
[Plausibility of the therapy concept].
Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete, 61(10), 826-827 (2010-10-12)
M Victoria González-Rodríguez et al.
Journal of separation science, 33(22), 3595-3603 (2010-10-12)
This article investigates the applicability of HPLC-UV, ultra performance LC-evaporative light-scattering detection (UPLC-ELSD), HPLC-ESI(+)-MS and HPLC-hybrid linear ion trap (LTQ) Orbitrap MS for the analysis of different non-ionic antistatic additives, Span 20, Span 60, Span 65, Span 80, Span 85
Determination of sorbitan trioleate in metered-dose inhalers by supercritical-fluid chromatography.
M Di Maso et al.
Journal of pharmaceutical and biomedical analysis, 8(3), 303-305 (1990-01-01)

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