S7152

Sigma-Aldrich

Ser-Phe-Leu-Leu-Arg-Asn-Pro-Asn-Asp-Lys-Tyr-Glu-Pro-Phe

≥97% (HPLC)

Synonym(s):
TRAP, SFLLRNPNDKYEPF, Thrombin Receptor Activator Peptide
Empirical Formula (Hill Notation):
C81H118N20O23
CAS Number:
Molecular Weight:
1739.92
MDL number:
PubChem Substance ID:
NACRES:
NA.26

Quality Level

assay

≥97% (HPLC)

form

powder

composition

Peptide content, ~70%

application(s)

ELISA: suitable
ligand binding assay: suitable

color

white

storage temp.

−20°C

SMILES string

CC(C)CC(NC(=O)C(CC(C)C)NC(=O)C(Cc1ccccc1)NC(=O)C(N)CO)C(=O)NC(CCCNC(N)=N)C(=O)NC(CC(N)=O)C(=O)N2CCCC2C(=O)NC(CC(N)=O)C(=O)NC(CC(O)=O)C(=O)NC(CCCCN)C(=O)NC(Cc3ccc(O)cc3)C(=O)NC(CCC(O)=O)C(=O)N4CCCC4C(=O)NC(Cc5ccccc5)C(O)=O

InChI

1S/C81H118N20O23/c1-43(2)34-53(93-71(114)54(35-44(3)4)94-73(116)55(92-67(110)49(83)42-102)36-45-16-7-5-8-17-45)70(113)90-51(21-13-31-88-81(86)87)69(112)98-59(40-64(85)105)79(122)101-33-15-22-61(101)76(119)97-57(39-63(84)104)74(117)96-58(41-66(108)109)75(118)89-50(20-11-12-30-82)68(111)95-56(37-47-24-26-48(103)27-25-47)72(115)91-52(28-29-65(106)107)78(121)100-32-14-23-62(100)77(120)99-60(80(123)124)38-46-18-9-6-10-19-46/h5-10,16-19,24-27,43-44,49-62,102-103H,11-15,20-23,28-42,82-83H2,1-4H3,(H2,84,104)(H2,85,105)(H,89,118)(H,90,113)(H,91,115)(H,92,110)(H,93,114)(H,94,116)(H,95,111)(H,96,117)(H,97,119)(H,98,112)(H,99,120)(H,106,107)(H,108,109)(H,123,124)(H4,86,87,88)

InChI key

OXHYRVSBKWIFES-UHFFFAOYSA-N

Related Categories

Amino Acid Sequence

Ser-Phe-Leu-Leu-Arg-Asn-Pro-Asn-Asp-Lys-Tyr-Glu-Pro-Phe

Packaging

1 mg in glass bottle
250 μg in glass bottle

Biochem/physiol Actions

Ser-Phe-Leu-Leu-Arg-Asn-Pro-Asn-Asp-Lys-Tyr-Glu-Pro-Phe has contractile effects on vascular and gastric smooth muscle. It stimulates the hydrolysis of phosphoinositides.
Thrombin receptor activator

Other Notes

Lyophilized from 0.1% TFA in H2O

storage_class_code

13 - Non Combustible Solids

WGK Germany

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US),Eyeshields,Gloves

Certificate of Analysis

Certificate of Origin

Relaxant and contractile responses of porcine pulmonary arteries to a thrombin receptor activating peptide (TRAP)
Glusa E and Manfred P
Naunyn-Schmiedeberg'S Archives of Pharmacology, 394(4), 431-443 (1994)
Sirasate Bantuchai et al.
International journal for parasitology, 49(9), 725-735 (2019-06-28)
The malaria parasite sporozoite sequentially invades mosquito salivary glands and mammalian hepatocytes; and is the Plasmodium lifecycle infective form mediating parasite transmission by the mosquito vector. The identification of several sporozoite-specific secretory proteins involved in invasion has revealed that sporozoite...
Rui Shu et al.
PloS one, 12(1), e0167312-e0167312 (2017-01-13)
Tooth movement is a biological process of bone remodeling induced by mechanical force. Sclerostin secreted by osteocytes is mechanosensory and important in bone remodeling. However, little is known regarding the role of sclerostin in tooth movement. In this study, models...
Xuzhuo Chen et al.
Experimental cell research, 382(1), 111470-111470 (2019-06-19)
Bone resorption, initiated by osteoclasts (OCs), plays an essential role in bone homeostasis. The abnormalities of bone resorption may induce a series of diseases, including osteoarthritis, osteoporosis and aseptic peri-implant loosening. Nirogacestat (PF-03084014, PF), a novel gamma-secretase inhibitor, has been...
Xiaolin Xu et al.
Experimental animals, 68(3), 371-380 (2019-04-05)
Ketogenic diet (KD) has been used in epilepsy for decades, but previous studies found it may cause severe bone loss. Every-other-day ketogenic diet (EODKD), the combination of KD with intermittent fasting, showed better potential for seizure control recently, while its...

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