The solubility of this product is tested with DMSO at a concentration of 10 mg/mL. External sources also recommend using DMSO. A literature search indicates that this product has been utilized in in vitro assays targeting human neutrophil elastase as a positive control.
S7198
Sivelestat sodium salt hydrate
≥98% (HPLC), HNE inhibitor, solid
Synonym(s):
EI 546 sodium salt hydrate, Elaspol sodium salt hydrate, LY 544349 sodium salt hydrate, Ono-5046 sodium salt hydrate, o-(p-Hydroxybenzenesulfonamido)hippuric acid, pivalate (ester) sodium salt hydrate
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5 MG
$119.00
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$491.00
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About This Item
Empirical Formula (Hill Notation):
C20H22N2O7S · xNa+ · yH2O
CAS Number:
Molecular Weight:
434.46 (anhydrous free acid basis)
UNSPSC Code:
12352200
NACRES:
NA.77
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Product Name
Sivelestat sodium salt hydrate, ≥98% (HPLC), solid
Quality Level
assay
≥98% (HPLC)
form
solid
color
white to off-white
solubility
DMSO: 10 mg/mL, clear
Storage temp.
room temp
SMILES string
[S](=O)(=O)(Nc2c(cccc2)C(=O)NCC(=O)O)c1ccc(cc1)OC(=O)C(C)(C)C
InChI
1S/C20H22N2O7S/c1-20(2,3)19(26)29-13-8-10-14(11-9-13)30(27,28)22-16-7-5-4-6-15(16)18(25)21-12-17(23)24/h4-11,22H,12H2,1-3H3,(H,21,25)(H,23,24)
Inchi Key
BTGNGJJLZOIYID-UHFFFAOYSA-N
Related Categories
1 of 4
This Item | M3935 | 61668 | T133 |
|---|---|---|---|
| assay ≥98% (HPLC) | assay ≥98% (HPLC) | assay ≥95.0% (TLC), 95-102% anhydrous basis (corrected for sodium, T) | assay ≥98% (HPLC) |
| form solid | form powder | form powder or solid | form powder |
| Quality Level 100 | Quality Level - | Quality Level 100 | Quality Level 100 |
| storage temp. room temp | storage temp. room temp | storage temp. 2-8°C | storage temp. - |
| solubility DMSO: 10 mg/mL, clear | solubility DMSO: 5 mg/mL, clear | solubility - | solubility H2O: soluble (storage of solutions for more than 8 hours at 4°C is not recommended.) |
| color white to off-white | color light yellow to dark yellow | color - | color light yellow |
Application
Sivelestat sodium salt hydrate may be used to inhibit human neutrophil elastase-mediated cell signaling.
Biochem/physiol Actions
Sivelestat is a competitive human neutrophil elastase (HNE) inhibitor (IC50 = 44 nM, Ki = 0.2 μM). It also inhibits leukocyte elastase obtained from rabbit, rat, hamster and mouse (IC50 = 19 to 49 nM). However, it does not inhibit trypsin, thrombin, plasmin, plasma kallikrein, pancreas kallikrein, chymotrypsin and cathepsin G even at 100 μM. In in-vivo studies, it suppressed lung hemorrhage in hamster (ID50 = 82 μg/kg) by intratracheal administration and increase of skin capillary permeability in guinea pig (ID50 = 9.6 mg/kg) by intravenous administration, both of which were induced by human neutrophil elastase.
Sivelestat is a competitive human neutrophil elastase (HNE) inhibitor.
Storage Class
11 - Combustible Solids
wgk_germany
nwg
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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Katja Herges et al.
Multiple sclerosis (Houndmills, Basingstoke, England), 18(4), 398-408 (2012-02-22)
The pathology of neuromyelitis optica (NMO), in contrast to multiple sclerosis, comprises granulocyte infiltrates along extensive lengths of spinal cord, as well as optic nerve. Furthermore, IFN-β treatment worsens NMO. We recently found that experimental autoimmune encephalomyelitis (EAE) induced with
Shuoqi Zhang et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 35(9), e21835-e21835 (2021-08-28)
Circulating neutrophil extracellular traps (NETs) resistant to t-PA have not been studied completely although NETs in thrombi may contribute to tissue plasminogen activator (t-PA) resistance. This research intended to elucidate whether circulating NETs are associated with t-PA resistance and the
Linshui Zhou et al.
Journal of cellular and molecular medicine, 24(20), 11998-12007 (2020-09-17)
The transition of alveolar type II epithelial cells into fibroblasts has been reported to cause and/or aggravate pulmonary fibrosis (PF), which is characterized by fibroblast proliferation, an enhanced production and accumulation of ECM (extracellular matrix), alveolar wall damage and functional
Biswajit Khatua et al.
Journal of leukocyte biology, 91(4), 641-655 (2012-01-14)
PA is an opportunistic pathogen that is commonly associated with severe infection in immunocompromised hosts. Siglec-9 binds with Sias by cis interaction on the neutrophil surface, thereby reducing immunological activity. However, neutrophils bind with pathogens through trans interactions of siglec-9
Naoya Fujino et al.
Experimental lung research, 38(1), 28-36 (2011-12-14)
Excess production of neutrophil elastase contributes to the pathogenesis of acute lung injury (ALI) and acute respiratory distress syndrome (ARDS). However, the role of neutrophil elastase in the repair process following ALI/ARDS is not well understood. The objective of this
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This compound can be used in in vitro assays targeting human neutrophil elastase as a positive control and is water-soluble?
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