S7947

Stattic

≥98% (HPLC), powder

• Synonym(s): 6-Nitrobenzo[b]thiophene-1,1-dioxide, Stat three inhibitory compound
• Empirical Formula (Hill Notation): C₈H₅NO₄S
• CAS Number: 19983-44-9
• Molecular Weight: 211.19
• MDL number: MFCD00173799
• PubChem Substance ID: 329824592
• NACRES: NA.77

Properties

• Quality Level: 100
• Assay: ≥98% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: >20 mg/mL
• SMILES string: [O-][N+](=O)c1ccc2C=CS(=O)(=O)c2c1
• InChI: 1S/C8H5NO4S/c10-9(11)7-2-1-6-3-4-14(12,13)8(6)5-7/h1-5H
• InChI key: ZRRGOUHITGRLBA-UHFFFAOYSA-N

Description

Application

Stattic has been used to inhibit signal transducer and activator of transcription 3 (STAT3) activity in various cell lines and culture.

Stattic was used to study Stat3-mediated cell signaling in human lung carcinoma cells.⁵

Biochem/physiol Actions

Stattic (Stat3 three inhibitory compound) alters the SH2 domain of Stat3 and indirectly inhibits with phosphopeptide binding. It is readily transported across the cell membrane compared to other phosphopeptides.² Stattic induces increased formation of ROS and negatively affects the cardiomyocyte mitochondrial function,³ and sensitizes nasopharyngeal carcinoma cells to chemoradiotherapy.⁴

Stattic is an irreversible STAT3 activation inhibitor.

Safety Information

• Pictograms: GHS07
• Signal Word: Warning
• Hazard Statements: H302 - H315 - H319 - H335
• Precautionary Statements: P261 - P264 - P270 - P301 + P312 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• Target Organs: Respiratory system
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves