S8442

SU 5416

≥98% (HPLC), powder, neuronal nitric oxide synthase inhibitor

• Synonym(s): 1,3-Dihydro-3-[(3,5-dimethyl-1H-pyrrol-2-yl)methylene]-2H-indol-2-one
• Empirical Formula (Hill Notation): C₁₅H₁₄N₂O
• CAS Number: 204005-46-9
• Molecular Weight: 238.28
• MDL number: MFCD01940922
• UNSPSC Code: 51111800
• PubChem Substance ID: 24278606
• NACRES: NA.77

Properties

• Product Name: SU 5416, ≥98% (HPLC)
• Quality Level: 100
• assay: ≥98% (HPLC)
• form: powder
• color: yellow to yellow-orange
• mp: 221-222 °C
• solubility: DMSO: 20 mg/mL, clear (warmed); H₂O: insoluble
• storage temp.: −20°C
• SMILES string: Cc1cc(C)c(C=C2C(=O)Nc3ccccc23)[nH]1
• InChI: 1S/C15H14N2O/c1-9-7-10(2)16-14(9)8-12-11-5-3-4-6-13(11)17-15(12)18/h3-8,16H,1-2H3,(H,17,18)/b12-8+
• InChI key: WUWDLXZGHZSWQZ-XYOKQWHBSA-N
• Gene Information: human ... EGFR(1956), FLT1(2321), IGFBP1(3484), IL2(3558), KDR(3791), PDGFRB(5159) ; mouse ... Flt1(14254), Kdr(16542)

Description

General description

SU 5416 is a vascular endothelial growth factor (VEGF) receptor protein tyrosine kinase 1/2 inhibitor. SU 5416 is known to prevent tumor growth and tumor angiogenesis.[1] SU 5416 inhibits the activity of neuronal nitric oxide synthase and protects the neuronal cells from nitric oxide-mediated neurotoxicity. It also acts as an agonist of aryl hydrocarbon receptor and may be an effective clinical agent for treating autoimmune diseases and transplant rejection.[2]

Application

SU 5416 has been used to treat HUVEC cells before the tube formation assay to assess its impact on the network generated from tube formation.[3] to induce pulmonary hypertension (PH) in mice to serve as an experimental model[4]

Biochem/physiol Actions

SU 516 inhibits the activity of neuronal nitric oxide synthase and protects the neuronal cells from nitric oxide-mediated neurotoxicity.¹ It also acts an agonist of aryl hydrocarbon receptor and is an effective clinical agent for treating autoimmune diseases and transplant rejection.²

SU 5416 is a vascular endothelial growth factor (VEGF) receptor protein tyrosine kinase 1/2 inhibitor.

Features and Benefits

This compound is a featured product for Kinase Phosphatase Biology research. Click here to discover more featured Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• ppe: dust mask type N95 (US), Eyeshields, Gloves