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S9192

Sigma-Aldrich

Ser-Leu-Ile-Gly-Lys-Val-amide

≥95% (HPLC), solid

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Synonym(s):
PAR-2 (1-6) Human, PAR2 activating peptide, PAR2-AP, SLIGKV-NH2
Empirical Formula (Hill Notation):
C28H54N8O7
CAS Number:
Molecular Weight:
614.78
MDL number:
PubChem Substance ID:
NACRES:
NA.32

Quality Level

assay

≥95% (HPLC)

form

solid

UniProt accession no.

storage temp.

−20°C

SMILES string

CC[C@H](C)[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)CO)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C(C)C)C(N)=O

InChI

1S/C28H54N8O7/c1-7-17(6)23(36-27(42)20(12-15(2)3)34-25(40)18(30)14-37)28(43)32-13-21(38)33-19(10-8-9-11-29)26(41)35-22(16(4)5)24(31)39/h15-20,22-23,37H,7-14,29-30H2,1-6H3,(H2,31,39)(H,32,43)(H,33,38)(H,34,40)(H,35,41)(H,36,42)/t17-,18-,19-,20-,22-,23-/m0/s1

InChI key

HOWDUIVVWDUEED-WAUHAFJUSA-N

Gene Information

mouse ... Insrr(23920)

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S9317S1820A3227
Ser-Leu-Ile-Gly-Lys-Val-amide ≥95% (HPLC), solid

S9192

Ser-Leu-Ile-Gly-Lys-Val-amide

Quality Level

200

Quality Level

200

Quality Level

-

Quality Level

-

form

solid

form

solid

form

lyophilized powder

form

lyophilized powder

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

Gene Information

mouse ... Insrr(23920)

Gene Information

-

Gene Information

human ... IGF1R(3480)

Gene Information

-

UniProt accession no.

Q9WTL4

UniProt accession no.

-

UniProt accession no.

P08069

UniProt accession no.

-

Amino Acid Sequence

Ser-Leu-Ile-Gly-Lys-Val-NH2

Biochem/physiol Actions

Proteinase-activated receptor (PAR-2) is a member of proteolytically cleaved receptors. It is activated by a synthetic peptide (SLIGKV), that is exposed after trypsin cleavage of the amino terminus. PAR-2 stimulates an increase in cytosolic Ca2+ ion concentration.
Proteinase-activated receptor-2 (PAR2)-activating peptide.

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

Other Notes

Lyophilized from 0.1% TFA in H2O

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)


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Molecular cloning, expression and potential functions of the human proteinase-activated receptor-2
BoHM SK, et al.
The Biochemical Journal, 314(3), 1009-1016 (1996)
Kenjiro Kaji et al.
Veterinary pathology, 58(1), 53-62 (2020-10-16)
Protease-activated receptor-2 (PAR2) is a G protein-coupled receptor that is activated by serine proteases. In humans, PAR2 is highly expressed in various cancers, including breast cancer, and is associated with cancer progression and metastasis. However, the expression and roles of
Induction of vascular smooth muscle cell growth by selective activation of the proteinase activated receptor-2 (PAR-2)
Bono F, et al.
Biochemical and Biophysical Research Communications, 241(3), 762-764 (1997)
Induction of Vascular Smooth Muscle Cell Growth by Selective Activation of the Proteinase Activated Receptor-2 (PAR-2)
F. Bono
Biochemical and Biophysical Research Communications (1997)
Abhishek Roy et al.
The Journal of biological chemistry, 292(33), 13688-13701 (2017-05-20)
Cell migration and invasion are very characteristic features of cancer cells that promote metastasis, which is one of the most common causes of mortality among cancer patients. Emerging evidence has shown that coagulation factors can directly mediate cancer-associated complications either

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