SAB1300499

Anti-PPM1E (N-term) antibody produced in rabbit

saturated ammonium sulfate (SAS) precipitated, buffered aqueous solution

• Synonym(s): Anti-PP2C-eta, Anti-PP2CE, Anti-PPM1M, Anti-Protein phosphatase 1M, Protein phosphatase 2C isoform eta
• UNSPSC Code: 12352203
• NACRES: NA.41

Properties

• biological source: rabbit
• Quality Level: 100
• conjugate: unconjugated
• antibody form: saturated ammonium sulfate (SAS) precipitated
• antibody product type: primary antibodies
• clone: polyclonal
• form: buffered aqueous solution
• species reactivity: human
• technique(s): indirect ELISA: 1:1000; western blot: 1:100-1:500
• NCBI accession no.: NP_653242
• UniProt accession no.: Q96MI6
• shipped in: dry ice
• storage temp.: −20°C
• target post-translational modification: unmodified
• Gene Information: human ... PPM1E(132160)

Description

General description

PPM1M is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase was identified as an interacting protein of Rho guanine nucleotide exchange factors (PIX). PIX proteins are regulators of p21/Cdc42/Rac1-activated kinase 1 (PAK1), a protein kinase mediating biological effects downstream of Rho GTPases. This phosphatase has been shown to block the effects of PAK, and thus inhibit actin stress fiber breakdown and morphological changes driven by cell division cycle 42 (CDC42).

Immunogen

PPM1E (NP_653242, 7-38)
This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the N-terminal region of human PPM1E.

Physical form

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.

Safety Information

• Storage Class: 10 - Combustible liquids
• wgk_germany: nwg
• flash_point_f: Not applicable
• flash_point_c: Not applicable