SPP, which localizes to the endoplasmic reticulum, catalyzes intramembrane proteolysis of some signal peptides after they have been cleaved from a preprotein. This activity is required to generate signal sequence-derived human lymphocyte antigen-E epitopes that are recognized by the immune system, and to process hepatitis C virus core protein. This protein is an integral membrane protein with sequence motifs characteristic of the presenilin-type aspartic proteases.
SPP (NP_848696, 1-30) This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the N-terminal region of human SPP.
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.
Storage Class Code
12 - Non Combustible Liquids
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