SAB1305554

Anti-β-Actin (ACTB) Antibody

Name: Anti-β-Actin (ACTB) Antibody
Brand: SIGMA
Price: 532 USD

mouse monoclonal, 137CT26.1.1

Synonym(s):

ACTB, Actin, cytoplasmic 1, Actin, cytoplasmic 1, N-terminally processed, Beta-actin

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400 μL

$532.00

Usually ships in 5 business days. (Orders outside of US, please allow an additional 1-2 weeks for delivery)

A recombinant, preservative-free antibody is available for your target. Try ZMS1156

About This Item

UNSPSC Code:

12352203

NACRES:

NA.41

Clone:

137CT26.1.1, monoclonal

Species reactivity:

mouse, human

Application:

IF, IHC, WB

Citations:

Key Documents

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Product Name

MONOCLONAL ANTI-BETA-ACTIN antibody produced in mouse, clone 137CT26.1.1, IgG fraction of antiserum, buffered aqueous solution

biological source

mouse

antibody form

IgG fraction of antiserum

antibody product type

primary antibodies

clone

137CT26.1.1, monoclonal

form

buffered aqueous solution

mol wt

41737 Da

species reactivity

mouse, human

technique(s)

immunofluorescence: 1:10-1:50, immunohistochemistry: 1:25, western blot: 1:1000

isotype

IgG1κ

NCBI accession no.

NP_001092.1

UniProt accession no.

P60709

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Quality Level

100

Gene Information

human ... ACTB(60)

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1 of 4

This Item	A2228	A5316	A5441
$MONOCLONAL ANTI-BETA-ACTIN antibody produced in mouse clone 137CT26.1.1, IgG fraction of antiserum, buffered aqueous solution$ Sigma-Aldrich SAB1305554 MONOCLONAL ANTI-BETA-ACTIN antibody produced in mouse	Sigma-Aldrich A2228 Monoclonal Anti-β-Actin antibody produced in mouse	Sigma-Aldrich A5316 Monoclonal Anti-β-Actin antibody produced in mouse	Sigma-Aldrich A5441 Monoclonal Anti-β-Actin antibody produced in mouse
clone 137CT26.1.1, monoclonal	clone AC-74, monoclonal	clone AC-74, monoclonal	clone AC-15, monoclonal
Gene Information human ... ACTB(60)	Gene Information human ... ACTB(60) mouse ... Actb(11461) rat ... Actb(81822)	Gene Information human ... ACTB(60) mouse ... Actb(11461) rat ... Actb(81822)	Gene Information human ... ACTB(60) mouse ... Actb(11461) rat ... Actb(81822)
antibody form IgG fraction of antiserum	antibody form purified immunoglobulin	antibody form ascites fluid	antibody form ascites fluid
biological source mouse	biological source mouse	biological source mouse	biological source mouse
species reactivity mouse, human	species reactivity rabbit, sheep, cat, guinea pig, bovine, mouse, chicken, wide range, Hirudo medicinalis, canine, Drosophila, carp, pig, rat, human	species reactivity rabbit, sheep, cat, guinea pig, bovine, mouse, chicken, wide range, Hirudo medicinalis, canine, Drosophila, carp, pig, rat, human	species reactivity sheep, carp, feline, chicken, rat, mouse, Hirudo medicinalis, rabbit, canine, pig, human, bovine, guinea pig
UniProt accession no. P60709	UniProt accession no. P60709	UniProt accession no. P60709	UniProt accession no. P60709

General description

β-actin (ACTB), a member of the actin multigene family, is an isoform of actin-associated with non-muscle cells. ACTB is a housekeeping gene mapped to human chromosome 7p22.1.

Application

Monoclonal Anti-Beta-Actin antibody produced in mouse has been used in western blotting at a dilution of 1:1000.

Biochem/physiol Actions

β-actin (ACTB) forms the core of the cell cytoskeleton. The polymerization of β-actin is essential for cell physiology. It may serve as a potential chemotherapeutic agent. Mutation in the ACTB gene is implicated in sensory hearing loss, delayed-onset generalized dystonia and a combination of ventral midline malformations. A loss-of-function mutation in the ACTB gene may cause intellectual disability.

Physical form

Supplied in PBS with 0.09% (W/V) sodium azide

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class

10 - Combustible liquids

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number

SG100806AD

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Induction of drug resistance in human hepatoma cells cultured on a silicate fiber based 3d scaffold

Mizutami T, et al.

Advances in Biochemical Engineering null

ACTB Loss-of-Function Mutations Result in a Pleiotropic Developmental Disorder.

Sara Cuvertino et al.

American journal of human genetics, 101(6), 1021-1033 (2017-12-09)

ACTB encodes β-actin, an abundant cytoskeletal housekeeping protein. In humans, postulated gain-of-function missense mutations cause Baraitser-Winter syndrome (BRWS), characterized by intellectual disability, cortical malformations, coloboma, sensorineural deafness, and typical facial features. To date, the consequences of loss-of-function ACTB mutations have

An Unbalanced Chromosome Translocation Between 7p22 and 12q13 Leads to ACTB-GLI1 Fusion in Pericytoma.

Ioannis Panagopoulos et al.

Anticancer research, 40(3), 1239-1245 (2020-03-07)

Since the first description of five pericytomas with the t(7;12)/ACTB-GLI1 fusion gene, only three new tumors were studied by both cytogenetics and molecular techniques. We report here genetic data on another case of this rare tumor. Cytogenetic, fluorescence in situ

Sequence and structural analysis of beta-actin protein of fishes, using bioinformatics tools and techniques

Acharya UR, et al.

International journal of biosciences, 4(11) (2014)

Antioxidant and Anti-Apoptotic Neuroprotective Effects of Cinnamon in Imiquimod-Induced Lupus.

Georges Maalouly et al.

Antioxidants (Basel, Switzerland), 13(7) (2024-07-27)

Despite accumulating evidence correlating oxidative stress with lupus disease activity, the brain redox pathways are still poorly investigated. Cinnamomum cassia, a widely used spice with powerful antioxidant properties, could be a novel therapeutic candidate in lupus. C57BL/6J female mice were

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