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SAB1306492

Sigma-Aldrich

ANTI-ZO1(C-TERMINAL) antibody produced in rabbit

purified immunoglobulin, buffered aqueous solution

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Synonym(s):
TJP1, Tight junction protein 1, Tight junction protein ZO-1, ZO1, Zona occludens protein 1
NACRES:
NA.41

biological source

rabbit

Quality Level

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

195459 Da

species reactivity

human

technique(s)

flow cytometry: 1:10-1:50
immunohistochemistry: 1:50-1:100
western blot: 1:1000

NCBI accession no.

UniProt accession no.

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... TJP1(7082)

Related Categories

General description

Tight junction protein 1 (TJP1) or zona occludens protein 1 (ZO1) is an adaptor protein. It acts as a scaffold protein between the tight junction and actin cytoskeleton. ZO1 has a molecular weight of 220kDa and is part of the membrane-associated guanylate kinase homolog family. The protein possesses three PDZ domains at its amino terminal, an SH3 domain and a region which bears homology to guanylate kinase. The ZO1 gene is localized on human chromosome 15q13.1.

Application

ANTI-ZO1(C-TERMINAL) antibody produced in rabbit has been used in immunofluorescence.

Biochem/physiol Actions

Tight junction protein 1 (TJP1) or zona occludens protein 1 (ZO1) has a role in the formation of epithelial lumens. It interacts with occludin and modulates tight junction barrier regulation. ZO1 is also involved in the formation of the odontoblast layer and in actomyosin cytoskeleton regulation. Low expression of ZO1 has been linked to increased cell invasiveness in breast cancer, colorectal cancer and digestive tract cancers.

Physical form

Supplied in PBS with 0.09% (W/V) sodium azide

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Storage Class

10 - Combustible liquids

flash_point_f

Not applicable

flash_point_c

Not applicable


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