Ye Liu et al.
Molecular therapy. Nucleic acids, 17, 113-125 (2019-06-30)
The receptor-associated prorenin system refers to the pathogenic mechanism whereby prorenin binding to (pro)renin receptor [(P)RR] dually activates the tissue renin-angiotensin system (RAS) and RAS-independent signaling, and its activation contributes to the molecular pathogenesis of various ocular diseases. We recently...
Giorgia Fanelli et al.
Scientific reports, 7(1), 14625-14625 (2017-11-09)
Age-related macular degeneration (AMD) is a major cause of blindness and is associated with complement dysregulation. The disease is a potential target for stem cell therapy but success is likely to be limited by the inflammatory response. We investigated the...
Rajalekshmy Shyam et al.
Proceedings of the National Academy of Sciences of the United States of America, 114(41), 10882-10887 (2017-09-07)
Carotenoids are plant-derived pigment molecules that vertebrates cannot synthesize de novo that protect the fovea of the primate retina from oxidative stress and light damage.
Anni Sorkio et al.
Journal of tissue engineering and regenerative medicine, 11(11), 3134-3144 (2017-01-05)
Human embryonic stem cell-derived retinal pigment epithelial (hESC-RPE) cell therapies show tremendous potential for the treatment of retinal degenerative diseases. A tissue engineering approach, where cells are delivered to the subretinal space on a biodegradable carrier as a sheet, shows...