SAB2501686
Anti-NOX1 antibody produced in goat
affinity isolated antibody, buffered aqueous solution
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All Photos(3)
Synonym(s):
GP91-2, MOX1, NADPH oxidase 1, NOH-1
UNSPSC Code:
12352203
NACRES:
NA.41
Recommended Products
biological source
goat
Quality Level
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
species reactivity
mouse, human, bovine, canine
technique(s)
indirect ELISA: suitable
western blot: suitable
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... NOX1(27035)
General description
NADPH oxidase 1 (NOX1) is encoded by the gene mapped to human chromosome Xq22.1. The protein belongs to the family of NADPH oxidases and is co-localized with caveolin in punctate patches on the surface and laterally on the cellular margins. NOX1 is mainly expressed in colon epithelium.
Immunogen
Peptide with sequence C-DKATDIVTGLKQK, from the internal region of the protein sequence according toNP_008983.2; NP_39249.1
Application
Anti-NOX1 antibody produced in goat has been used for Western blotting.
Biochem/physiol Actions
NOX1 catalyzes the production of hydrogen peroxide (H2O2). Overexpression of the protein leads to the production of superoxide and H2O2 and triggers angiogenic switch, mediating vascularization and rapid expansion of the tumor. Elevated expression of NOX1 has been observed in the brain of Parkinson′s disease (PD) patients.
Features and Benefits
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
Physical form
Supplied at 0.5 mg/mL in 20mM Tris (pH 7.3) and 150mM NaCl with 0.02% sodium azide and 0.5% bovine serum albumin.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
wgk_germany
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificates of Analysis (COA)
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Find documentation for the products that you have recently purchased in the Document Library.
Nox1 NADPH oxidase is necessary for late but not early myocardial ischaemic preconditioning
Shuxia Jiang
Cardiovascular Research, 102(1) (2014)
NADPH oxidases in Parkinson?s disease: a systematic review
Karim Belarbi
Molecular Neurobiology, 12(84) (2017)
Reactive oxygen generated by Nox1 triggers the angiogenic switch
Jack L
Proceedings of the National Academy of Sciences of the USA, 99(2), 715-720 (2000)
LRRC8A channels support TNFa-induced superoxide production by Nox1 which is required for receptor endocytosis
Hyehun Choi
Free Radical Biology & Medicine, 413-423 (2016)
Hyehun Choi et al.
Free radical biology & medicine, 101, 413-423 (2016-11-14)
Leucine Rich Repeat Containing 8A (LRRC8A) is a required component of volume-regulated anion channels (VRACs). In vascular smooth muscle cells, tumor necrosis factor-α (TNFα) activates VRAC via type 1 TNFα receptors (TNFR1), and this requires superoxide (O2•-) production by NADPH
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