Anti-GPC1 antibody produced in rabbit

affinity isolated antibody, buffered aqueous solution

glypican, FLJ38078, GPC1
Pricing and availability is not currently available.

biological source


antibody form

affinity isolated antibody

antibody product type

primary antibodies




buffered aqueous solution

species reactivity

human, mouse


ELISA: suitable
flow cytometry: suitable
immunofluorescence: suitable
immunohistochemistry: suitable
immunoprecipitation (IP): suitable
western blot: 500-3000



Featured Industry

Research Pathology

NCBI accession no.

UniProt accession no.

shipped in

wet ice

storage temp.


Gene Information

human ... GPC1(2817)

General description

Glypican 1 (GPC1) is located at 2q37.3 on the human chromosome. It belongs to the family of glycosylphosphatidylinositol-anchored heparan sulfate proteoglycan. GPC1 is localized in the vascular system. GPC1 consists of an N-terminal secretory signal peptide, 14 conserved cysteine residues, a heparan sulfate (HS) attachment domain near the C terminus and a hydrophobic domain for attachment of the glycosylphosphatidylinositol (GPI) at the C terminus.


Recombinant protein encompassing a sequence within the center region of human Glypican 1.


Suggested starting dilutions are as follows: ELISA: 1:1000-1:10000, FACS: 1:50-1:200, ICC/IF: 1:100-1:1000, IHC-F: Assay-dependent dilution, IHC-P: 1:100-1:1000, IP: 1:100-1:500, WB: 1:500-1:3000. Not yet tested in other applications. Optimal working dilutions should be determined experimentally by the end user.

Biochem/physiol Actions

Glypican 1 (GPC1) plays an important role in cell growth, differentiation and morphogenesis. It also plays a role in cell migration, adhesion, anti-coagulation, lipoprotein metabolism and modulation of growth factors. GPC1 exhibits chaperone-like activity by restoring the binding activity of oxidized VEGF165 (vascular endothelial growth factors-165). Overexpression of GPC1 results in over accumulation of β-amyloid protein (Aβ) in the Alzheimer′s disease (AD) brain. Mutation in this gene is associated with Niemann-Pick C1 disease.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Physical form

1XPBS, 20% Glycerol (pH7). 0.025% ProClin 300 was added as a preservative.


Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.


NONH for all modes of transport

WGK Germany


Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificate of Analysis
Certificate of Origin
Glypican-1 is a VEGF165 binding proteoglycan that acts as an extracellular chaperone for VEGF165
Gengrinovitch S, et al.
Test, 274(16), 10816-10822 (1999)
Defective nitric oxide-dependent, deaminative cleavage of glypican-1 heparan sulfate in Niemann-Pick C1 fibroblasts
Mani K, et al.
Glycobiology, 16(8), 711-718 (2006)
Molecular delineation of deletions on 2q37. 3 in three cases with an Albright hereditary osteodystrophy-like phenotype
Shrimpton A E, et al.
Clinical Genetics, 66(6), 537-544 (2004)
Crystal Structure of N-Glycosylated Human Glypican-1 Core Protein structure of Two Loops Evolutionarily Conserved in Vertebrate Glypican-1
Svensson G, et al.
The Journal of biological chemistry, 287(17), 14040-14051 (2012)

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