SAB2700878

Sigma-Aldrich

Anti-IL17RC antibody produced in rabbit

affinity isolated antibody, buffered aqueous solution

Synonym(s):
IL17RC, IL17-RL, FLJ95963, FLJ96005
NACRES:
NA.41

biological source

rabbit

Quality Level

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

species reactivity

human

application(s)

western blot: 1:500-1:3000

conjugate

unconjugated

NCBI accession no.

UniProt accession no.

shipped in

wet ice

storage temp.

−20°C

Gene Information

human ... IL17RC(84818)

General description

IL17RC (Interleukin 17 receptor C) is a novel single-pass transmembrane protein belonging to the interleukin-17 cytokine family. It is expressed in T cells and B cells with an extracellular N terminal domain. It is widely distributed in prostate, cartilage, kidney, liver, heart, and muscle, whereas at a lower level in thymus and leukocytes. It is mapped on human chromosome 3p25.3-3p24.1. Its expression has also been found in various cancerous cells such as prostate cancer.

Immunogen

Recombinant protein fragment contain a sequence corresponding to a region within amino acids 62 and 471 of Human Interleukin-17 receptor C according to NP_703191

Application

Anti-IL17RC antibody produced in rabbit is suitable for western blot anaysis.

Biochem/physiol Actions

IL17RC (Interleukin 17 receptor C) performs in the cytokine signaling pathway as a decoy receptor. It is essentially required for the signaling of IL-17A, IL-17F, and IL-17A/F both in vitro and in vivo. In nonhemopoietic tissues, it couples with IL-17RA and forms a complex, which drives the functions of IL-17A and IL-17F homodimers as well as IL-17A/F heterodimers. Inherited deficiency of IL17RC causes an autosomal recessive disorder, chronic mucocutaneous candidiasis (CMC), with recurrent or persistent infections of the skin, nail, oral, and genital mucosae.

Features and Benefits

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Physical form

0.1M Tris, 0.1M Glycine, 10% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.

storage_class_code

12 - Non Combustible Liquids

WGK Germany

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificate of Analysis

Certificate of Origin

Dominik Haudenschild et al.
The Journal of biological chemistry, 277(6), 4309-4316 (2001-11-14)
Members of the interleukin-17 cytokine family are present in a variety of tissues (1-3), although the founding member, interleukin-17, is expressed exclusively in T cells and B cells (4-8). The cloning and characterization of a novel single-pass transmembrane protein with...
Yan Hu et al.
Journal of immunology (Baltimore, Md. : 1950), 184(8), 4307-4316 (2010-03-17)
It has been suggested that IL-17RC forms a complex with IL-17RA to mediate the functions of IL-17A and IL-17F homodimers as well as IL-17A/F heterodimers. It is still unclear whether IL-17RC is absolutely required for the signaling of IL-17 cytokines...

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