NOTUM encodes palmitoleoyl-protein carboxylesterase. In human chromosome, the gene NOTUM is localized on 17q25.3.
NOTUM antibody was raised against a 19 amino acid peptide near the amino terminus of human NOTUM.
Anti-NOTUM antibody produced in rabbit has been used in immunostaining.
Notum is involved in the progression of colorectal cancer and its expression levels is higher in metastatic cells. Notum is one of the pain associated genes.
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In Drosophila, the notum gene is regulated by the Wingless pathway and encodes a secreted hydrolase that modifies heparan sulfate proteoglycans. The mammalian homolog has been shown to be able to cleave glypicans and can release GPI-anchored proteins from the mammalian cell surface. Like the Drosophilia NOTUM, the mammalian protein can act as a negative regulator of the Wnt signaling pathway. NOTUM is expressed at a low level in most mammalian tissues, although it is overexpressed in a subset of human hepatocellular carcinomas. Its transcription is regulated by β-catenin/TCF and is a target of the Wnt signaling pathway, forming a negative feedback loop that regulates the expression and activity of the Wnt pathway.
The action of this antibody can be blocked using blocking peptide SBP3500082.
Supplied at approx. 1 mg/mL in phosphate buffered saline containing 0.02% sodium azide.
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