SAB3500479

Sigma-Aldrich

Monoclonal Anti-IL-33 antibody produced in mouse

clone 12H6D12, purified immunoglobulin, buffered aqueous solution

Synonym(s):
Anti-Nuclear factor from high endothelial venules, Anti-Interleukin-33, Anti-NFHEV
NACRES:
NA.41

Quality Level

biological source

mouse

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

12H6D12, monoclonal

form

buffered aqueous solution

species reactivity

human, mouse

application(s)

immunohistochemistry: suitable
indirect ELISA: suitable
western blot: suitable

conjugate

unconjugated

NCBI accession no.

UniProt accession no.

shipped in

dry ice

storage temp.

−20°C

Gene Information

human ... IL33(90865)

General description

Interleukin 33 (IL-33) is a potent immunomodulatory cytokine that belongs to the IL-1 family. It is highly expressed in endothelial venules, endothelial cells and epithelium. The gene encoding this protein is localized on human chromosome 9p24.1.

Immunogen

Mouse monoclonal IL-33 antibody was raised against the recombinant IL-33 protein.

Biochem/physiol Actions

Interleukin 33 (IL-33) functions as an extracellular cytokine and also translocates to the nucleus where it inhibits gene expression. IL-33 enhances the secretion of inflammatory cytokines and is associated with T-helper 2-type immune responses. It has been linked to chronic inflammatory diseases. High levels of IL-33 have been observed in the serum of patients with hepatocellular carcinoma and gastric cancer. Polymorphisms in this gene as well as its receptor are linked with atopic dermatitis, allergies and asthma.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Physical form

Supplied in PBS with 0.02% sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

storage_class_code

12 - Non Combustible Liquids

WGK Germany

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificate of Analysis

Certificate of Origin

The IL-33/ST2 pathway: therapeutic target and novel biomarker
Rahul Kakkar and Richard T
Nature Reviews. Drug Discovery (2008)
Targeting the IL-1 family members in skin inflammation.
Jensen LE
Current Opinion in Investigational Drugs (2010)
IL-33-induced JNK pathway activation confers gastric cancer chemotherapy resistance.
Ye XL
Oncology Reports (2015)
Esophageal Epithelial-Derived IL-33 Is Upregulated in Patients with Heartburn.
Sei H
PLoS ONE (2016)
Rhinoviral stimuli, epithelial factors and ATP signalling contribute to bronchial smooth muscle production of IL-33.
Calven J
Journal of Translational Medicine (2015)

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service