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SAB3500536

Sigma-Aldrich

Anti-HVCN1 antibody produced in rabbit

affinity isolated antibody, buffered aqueous solution

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Synonym(s):
Anti-HV1, Anti-Hydrogen voltage-gated channel 1, Anti-VSOP, Anti-Voltage sensor domain-only protein
NACRES:
NA.41

biological source

rabbit

Quality Level

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

predicted mol wt 30 kDa

species reactivity

rat, human, mouse

technique(s)

immunofluorescence: suitable
immunohistochemistry: suitable
indirect ELISA: suitable
western blot: suitable

NCBI accession no.

UniProt accession no.

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... HVCN1(84329)

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This Item
SAB2900880HPA039329HPA019195
conjugate

unconjugated

conjugate

unconjugated

conjugate

unconjugated

conjugate

unconjugated

biological source

rabbit

biological source

rabbit

biological source

rabbit

biological source

rabbit

technique(s)

immunofluorescence: suitable, indirect ELISA: suitable, immunohistochemistry: suitable, western blot: suitable

technique(s)

ELISA: suitable, immunohistochemistry (formalin-fixed, paraffin-embedded sections): 5 μg/mL, western blot: 0.5-1.0 μg/mL

technique(s)

immunohistochemistry: 1:20- 1:50

technique(s)

immunoblotting: 0.04-0.4 μg/mL, immunohistochemistry: 1:200-1:500

form

buffered aqueous solution

form

buffered aqueous solution

form

buffered aqueous glycerol solution

form

buffered aqueous glycerol solution

species reactivity

rat, human, mouse

species reactivity

human, rat, mouse

species reactivity

human

species reactivity

human

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General description

Hydrogen voltage gated channel 1 (HVCN1) is a voltage gated proton channel and is needed for efflux of intracellular acid. The gene encoding it is localized on human chromosome 12q24.11.

Immunogen

HVCN1 antibody was raised against a 17 amino acid peptide near the carboxy terminus of human HVCN1.

Biochem/physiol Actions

Hydrogen voltage gated channel 1 (HVCN1) modulates insulin secretion by participating in Ca2+ homeostasis. In mice, the channel is involved in superoxide generation, bacterial removal from granulocytes and neutrophils and superoxide-associated B-cell receptor (BCR) signaling. HVCN1 might be associated with BCR-mediated B-cell malignancies.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Linkage

The action of this antibody can be blocked using blocking peptide SBP3500536.

Physical form

Supplied in PBS with 0.02% sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Related product

Product No.
Description
Pricing

Storage Class

10 - Combustible liquids

flash_point_f

Not applicable

flash_point_c

Not applicable


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The voltage-gated proton channel Hv1 is expressed in pancreatic islet ?-cells and regulates insulin secretion.
Zhao Q
Biochemical and Biophysical Research Communications (2015)
Voltage-Gated Proton Channels as Novel Drug Targets: From NADPH Oxidase Regulation to Sperm Biology
Tamara S
Antioxidants & Redox Signaling (2015)
Elaine Hayes et al.
Frontiers in immunology, 11, 600033-600033 (2021-01-05)
Studies have endeavored to understand the cause for impaired antimicrobial killing by neutrophils of people with cystic fibrosis (PWCF). The aim of this study was to focus on the bacterial phagosome. Possible alterations in degranulation of cytoplasmic granules and changes
Enhanced activation of an amino-terminally truncated isoform of the voltage-gated proton channel HVCN1 enriched in malignant B cells.
Hondares E
Proceedings of the National Academy of Sciences of the USA (2014)
Padraig Hawkins et al.
Medicina (Kaunas, Lithuania), 57(8) (2021-08-28)
Background and Objectives: Alpha-1 antitrypsin is a serine protease inhibitor that demonstrates an array of immunomodulatory functions. Individuals with the genetic condition of alpha-1 antitrypsin deficiency (AATD) are at increased risk of early onset emphysematous lung disease. This lung disease

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