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SAB3500757

Sigma-Aldrich

Anti-NKX2-1 antibody produced in rabbit

affinity isolated antibody

NACRES:
NA.41

biological source

rabbit

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

mol wt

41 kDa

species reactivity

human, rat, mouse

concentration

1 mg/mL

technique(s)

ELISA: suitable
western blot: suitable

NCBI accession no.

UniProt accession no.

shipped in

wet ice

storage temp.

−20°C

Gene Information

human ... NKX2-1(7080)

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This Item
HPA036774SAB3500652SAB3500653
conjugate

unconjugated

conjugate

unconjugated

conjugate

unconjugated

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody form

affinity isolated antibody

antibody form

affinity isolated antibody

antibody form

affinity isolated antibody

mol wt

41 kDa

mol wt

-

mol wt

39 kDa

mol wt

33 kDa

species reactivity

human, rat, mouse

species reactivity

human

species reactivity

human, mouse

species reactivity

mouse, human

concentration

1 mg/mL

concentration

-

concentration

1 mg/mL

concentration

1 mg/mL

General description

NK2 homeobox 1 (NKX2-1) is expressed in epithelial cells of the thyroid gland and lungs. The gene encoding NKX2-1 is localized on human chromosome 14q13.

Immunogen

Antibody was raised against a 16 amino acid peptide near the amino terminus of human NKX2-1.

Biochem/physiol Actions

NK2 homeobox 1(NKX2-1) has a role in the development of thyroid glands, lungs and brain. It modulates gene expression during embryogenesis. NKX2-1 has been found to be expressed in adenocarcinoma and small cell lung cancer. This protein acts as an immunohistological marker to distinguish between primary lung carcinoma and non-pulmonary cancer.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Linkage

The action of this antibody can be blocked using blocking peptide SBP3500757.

Physical form

Supplied at 1 mg/mL in PBS with 0.02% sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

related product

Product No.
Description
Pricing

Storage Class Code

10 - Combustible liquids

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


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Distinct expression of NK2 homeobox 1 (NKX2-1) and goblet cell hyperplasia in nasal polyps with different endotypes.
Du J, et al.
International Forum of Allergy & Rhinology, 7(7) (2017)
Lara López-González et al.
Brain structure & function, 228(2), 537-576 (2023-01-05)
The ventromedial hypothalamic nucleus (VMH) is one of the most distinctive hypothalamic tuberal structures, subject of numerous classic and modern functional studies. Commonly, the adult VMH has been divided in several portions, attending to differences in cell aggregation, cell type
Recurrent drop attacks in early childhood as presenting symptom of benign hereditary chorea caused by TITF1 gene mutations.
Rosati A, et al.
Developmental Medicine and Child Neurology, 57(8), 777-779 (2015)
Expression of thyroid transcription factor-1 is associated with a basal-like phenotype in breast carcinomas.
Klingen T A, et al.
Diagnostic Pathology, 8(1), 80-80 (2013)
Value of thyroid transcription factor (TTF)-1 for diagnosis and prognosis of patients with locally advanced or metastatic small cell lung cancer.
Misch D, et al.
Diagnostic Pathology, 10(1), 21-21 (2015)

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