Exosome component 2 (EXOSC2) gene is mapped to human chromosome 9q34. It comprises S1 RNA-binding domain and is a part of the three-subunit cap and a core exosome component.
EXOSC2 (Exosome component 2) is a non-catalytic subunit of the eukaryotic RNA exosome. It is localized in the nucleus and in the cytoplasm.
Anti-EXOSC2 recognizes human, mouse and rat EXOSC2.
peptide corresponding to the N-terminal region of human EXOSC2, conjugated to KLH. The corresponding sequence is identical in mouse, rat, monkey, bovine, pig and dog.
Anti-EXOSC2 antibody produced in rabbit is suitable for western blot at a concentration of 2.5-5.0μg/mL using whole extracts of human Jurkat, mouse A20 and rat PC12 cells.
Exosome component 2 (EXOSC2) gene mutations leads to alterations in its RNA binding and recruiting abilities. Biallelic mutations is implicated in facial gestalt and other associated anomalies.
EXOSC2 (Exosome component 2) is associated with several cellular processes such as rRNA processing, RNA degradation from the 3′ end, 3′ to 5′ decay of the mRNA body after its deadenylation. Exosome complex is an ~400kDa multimeric complex, which plays a vital role in substrate recognition. EXOSC2 functions as a cofactor in the maintenance of human exosome integrity and efficient degradation and/or metabolism of various RNA classes.
Solution in 0.01 M phosphate buffered saline pH 7.4, containing 15 mM sodium azide.
Storage and Stability
For continuous use, store at 2-8°C for up to one month. For extended storage freeze in workingaliquots. Repeated freezing and thawing is not recommended. If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use. Working dilution samples should be discarded if not used within 12 hours.
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.