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SAB4200508

Sigma-Aldrich

Anti-ARG1 antibody, Mouse monoclonal

clone ARG1-3, purified from hybridoma cell culture

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Synonym(s):
Anti-arginase-1, Anti-liver-type arginase, Anti-type I arginase, Monoclonal Anti-ARG1 antibody produced in mouse
NACRES:
NA.41

biological source

mouse

conjugate

unconjugated

antibody form

purified from hybridoma cell culture

antibody product type

primary antibodies

clone

ARG1-3, monoclonal

form

buffered aqueous solution

mol wt

antigen ~40 kDa

species reactivity

rat, human, mouse

concentration

~1.0 mg/mL

technique(s)

western blot: 2-4 μg/mL using whole extracts of rat or mouse liver.

UniProt accession no.

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... ARG1(383)

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This Item
SAB2501375HPA003595HPA024006
conjugate

unconjugated

conjugate

unconjugated

conjugate

unconjugated

conjugate

unconjugated

antibody form

purified from hybridoma cell culture

antibody form

affinity isolated antibody

antibody form

affinity isolated antibody

antibody form

affinity isolated antibody

clone

ARG1-3, monoclonal

clone

polyclonal

clone

polyclonal

clone

polyclonal

form

buffered aqueous solution

form

buffered aqueous solution

form

buffered aqueous glycerol solution

form

buffered aqueous glycerol solution

mol wt

antigen ~40 kDa

mol wt

-

mol wt

-

mol wt

-

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General description

Monoclonal Anti-ARG1 (mouse IgG1 isotype) is derived from the hybridoma ARG1-3 produced by the fusion of mouse myeloma cells and splenocytes from BALB/c mice immunized with a synthetic peptide. Arginase (ARG)1 gene, codes for type I isoform of arginase. ARG1 is a cytosolic enzyme expressed predominantly in the liver as a component of the urea cycle.

Immunogen

synthetic peptide corresponding to a sequence at the N-terminal region of human ARG1, conjugated to KLH. The corresponding sequence differs by 3 amino acids in mouse ARG1 and by 4 amino acids in rat ARG1.

Application

Monoclonal Anti-ARG1 antibody produced in mouse has been used in immunoblotting.

Biochem/physiol Actions

Arginase hydrolyzes arginine to ornithine and urea. Arginases have been implicated in many disease processes, including vascular diseases, pulmonary diseases, infectious diseases, immune cell dysfunction and cancer. Inherited deficiency of ARG1 enzyme results in argininemia, an autosomal recessive disorder characterized by hyperammonemia.

Physical form

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Storage Class Code

12 - Non Combustible Liquids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


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Molecular regulation of urea cycle function by the liver glucocorticoid receptor
Okun JG, et al.
Molecular Metabolism, 4(10), 732-740 (2015)
Arginase: a critical regulator of nitric oxide synthesis and vascular function
Durante W, et al.
Clinical and Experimental Pharmacology & Physiology, 34(9), 906-911 (2007)

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