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SAB4200574

Sigma-Aldrich

Anti-Claudin-4 (C-terminal) antibody produced in rabbit

affinity isolated antibody

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Synonym(s):
(CPER), CLDN4, CPE-R, CPETR1, Clostridium, Williams-Beuren syndrome chromosomal region 8(WBSCR8), enterotoxin, hCPE-R, perfringens, receptor
NACRES:
NA.41

biological source

rabbit

Quality Level

antibody form

affinity isolated antibody

antibody product type

primary antibodies

species reactivity

rat, human, canine

technique(s)

immunoblotting: suitable
immunofluorescence: suitable
immunohistochemistry: suitable

UniProt accession no.

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... CLDN4(1364)

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This Item
SAB4500433SAB4500432MABT140
biological source

rabbit

biological source

rabbit

biological source

rabbit

biological source

mouse

antibody form

affinity isolated antibody

antibody form

affinity isolated antibody

antibody form

affinity isolated antibody

antibody form

purified antibody

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

storage temp.

-

UniProt accession no.

P01275

UniProt accession no.

O14493

UniProt accession no.

O14493

UniProt accession no.

O14493

technique(s)

immunoblotting: suitable, immunohistochemistry: suitable, immunofluorescence: suitable

technique(s)

ELISA: 1:5000, immunohistochemistry: 1:50-1:100, western blot: 1:500-1:1000

technique(s)

ELISA: 1:1000, immunohistochemistry: 1:50-1:100, western blot: 1:500-1:1000

technique(s)

immunohistochemistry: suitable (paraffin), western blot: suitable

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General description

Claudin-4 is heterogeneously expressed in various tissues. It is enriched in endothelial cells (ECs), including the blood-brain barrier, and is also expressed in gut and kidney. It is mapped to human chromosome 7q11.23. Claudin-4 is associated with the tight junction strands in kidney epithelial cells.

Specificity

Anti-Claudin-4 (C-terminal) specifically recognizes human, rat and dog claudin-4.

Application

Anti-Claudin-4 (C-terminal) antibody produced in rabbit has been used in:
  • immunoblotting
  • immunofluorescence
  • immunohistochemistry

Biochem/physiol Actions

Claudin-4 is involved in maintaining cellular polarity. It favors sodium chloride absorption and acts as a cation-barrier. Claudin-4 expression has been shown to be deregulated in several cancers, with aberrant expression in ovarian, breast, prostate and pancreatic carcinomas. The gene location of claudin-4 is a Williams-Beuren syndrome critical region.

Physical form

Supplied as a solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

Storage and Stability

For continuous use, store at 2-8 °C for up to one month. For extended storage, freeze in working aliquots. Repeated freezing and thawing, or storage in “frost-free” freezers, is not recommended. If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use. Working dilutions should be discarded if not used within 12 hours.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Storage Class

10 - Combustible liquids

flash_point_f

Not applicable

flash_point_c

Not applicable


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Clinical utility gene card for: Williams-Beuren Syndrome [7q11. 23]
Koehler U, et al.
European Journal of Human Genetics, 22(9), 1153-1153 (2014)
Williams-Beuren syndrome: a challenge for genotype-phenotype correlations
Tassabehji, M
Human Molecular Genetics, 12, R229-R237 (2003)
Claudin-1,-2,-4, and-5: comparison of expression levels and distribution in equine tissues
Lee B, et al.
Journal of Veterinary Science, 17(4), 445-451 (2016)
Claudin-3 and claudin-4 expression in ovarian epithelial cells enhances invasion and is associated with increased matrix metalloproteinase-2 activity
Agarwal R, et al.
Cancer Research, 65(16), 7378-7385 (2005)

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