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SAB4200576

Sigma-Aldrich

Anti-COX2 antibody produced in rabbit

enhanced validation

~1.0 mg/mL, affinity isolated antibody

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NACRES:
NA.41

biological source

rabbit

Quality Level

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen ~75 kDa

species reactivity

human, mouse

enhanced validation

recombinant expression
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concentration

~1.0 mg/mL

technique(s)

indirect immunofluorescence: 5-10 μg/mL using RAW-264.7 cells stimulated with LPS
western blot: 1.5-3.0 μg/mL using lysates of RAW-264.7 cells stimulated with LPS, and of HEK-293T cells overexpressing human COX2

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... COX2(5743)

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This Item
N7782SAB4200067SAB4200178
conjugate

unconjugated

conjugate

unconjugated

conjugate

unconjugated

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody form

IgG fraction of antiserum

antibody form

affinity isolated antibody

antibody form

affinity isolated antibody

clone

polyclonal

clone

polyclonal

clone

polyclonal

clone

polyclonal

form

buffered aqueous solution

form

buffered aqueous solution

form

buffered aqueous solution

form

buffered aqueous solution

mol wt

antigen ~75 kDa

mol wt

antigen 130 kDa

mol wt

antigen ~45 kDa, antigen ~59 kDa

mol wt

antigen ~123 kDa

General description

Cytochrome c oxidase subunit II (COX2) is encoded by the gene mapped to human chromosome 1. The encoded protein is one of the isoforms of COX protein. It is expressed in specific cells such as activated macrophages, monocytes, neutrophils and lymphocytes, in response to inflammatory stimuli such as mitogen, cytokines and growth factors.

Immunogen

synthetic peptide corresponding to an internal sequence of human COX2 (GeneID: 5743), conjugated to KLH. The corresponding sequence has high homology to rat COX2 (83% identity) and to mouse COX2 (82% identity).

Application

Anti-COX2 antibody produced in rabbit has been used in immunohistochemical staining.

Biochem/physiol Actions

Cyclooxygenase (COX) catalyzes the conversion of arachidonic acid (AA) to prostaglandins (PG). Mutation in the gene is associated with the development of gastric cancer. Elevated expression of the gene has been observed in various chronic and autoimmune diseases.

Physical form

Solution in 0.01 M phos­phate buffered saline, pH 7.4, containing 15 mM sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Storage Class Code

10 - Combustible liquids

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


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Immunohistological study of the effect of extravirgin olive oil on aspartame-treated cerebellum of male albino rat
Baky F A F A .
Menoufia Medical Journal, 29(3), 728-728 (2016)
Expression of IL-17 and COX2 gene in peripheral blood leukocytes of vitiligo patients.
Esmaeili B, et al.
Iranian Journal of Allergy, Asthma, and Immunology, 10(2), 81-81 (2011)
Emilie Mathieu et al.
Chemical communications (Cambridge, England), 56(57), 7885-7888 (2020-06-11)
A conjugate of a Mn-based superoxide dismutase mimic with a Re-based multimodal probe 1[combining low line] was studied in a cellular model of oxidative stress. Its speciation was investigated using Re and Mn X-fluorescence. Interestingly, 1[combining low line] shows a
Anja Maier et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 31(11), 4971-4984 (2017-08-02)
Recently we identified hypoxia-inducible protein 2 (HIG2)/hypoxia-inducible lipid droplet-associated (HILPDA) as lipid droplet (LD) protein. Because HILPDA is highly expressed in atherosclerotic plaques, we examined its regulation and function in murine macrophages, compared it to the LD adipose differentiation-related protein
Detection and Clinical Significance of COX-2 Gene SNPs in Gastric Cancer.
Lu X, et al.
Cell Biochemistry and Biophysics, 72(3), 657-660 (2015)

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