Monoclonal Anti-Human IgG (Fc specific) (mouse IgG1 isotype) is derived from the GG-7 hybridoma, produced by the fusion of mouse myeloma cells and splenocytes from mouse immunized with Purified human IgG myeloma proteins covalently coupled to polyaminostyrene (PAS) microbeads. IgGs are the most common Immunoglobulins isotype in blood, lymph fluid, cerebrospinal fluid, and peritoneal fluid. IgGs include four subclasses (IgG1, IgG2, IgG3, and IgG4), they consist of a variable Fab fragment (which includes the antibody recognition site), and a conserved Fc fragment.
Purified human IgG myeloma proteins covalently coupled to polyaminostyrene (PAS) microbeads
Monoclonal Anti-Human IgG (Fc specific) antibody has been used in:
- Imprint Immunofixation (IIF)
- Immunofluorometric Assay (IFMA)
- Hemagglutination (HA)
- Hemagglutination Inhibition (HAI)
- Particle Counting Immunoassay (PACIA)
- detection of cytoplasmic IgG
The crystallizable fragment (Fc) of IgG has various important functions such as complement fixation, site for rheumatoid factor (autoantibody directed to Fc) attachment, passage through the placental membrane and protein A binding. IgG deficiencies are often associated with various diseases.
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.
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