MilliporeSigma
All Photos(2)

Documents

SAB4200684

Sigma-Aldrich

Monoclonal Anti-Uvomorulin/E-Cadherin antibody produced in rat

clone DECMA-1, purified from hybridoma cell culture

Sign Into View Organizational & Contract Pricing

Synonym(s):
Arc-1, CD324, CDHE, E-cadherin (epithelial), ECAD, LCAM, UVO, cadherin 1, type 1
NACRES:
NA.41

biological source

rat

Quality Level

conjugate

unconjugated

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

DECMA-1, monoclonal

form

buffered aqueous solution

mol wt

antigen ~120 kDa

species reactivity

dog, mouse

concentration

~1 mg/mL

technique(s)

immunoblotting: 0.5-1 μg/mL using whole extract of MDCK cells.
immunofluorescence: 5-10 μg/mL using MDCK cells
immunoprecipitation (IP): suitable

isotype

IgG1

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

mouse ... Cdh1(12550)

Compare Similar Items

View Full Comparison

Show Differences

1 of 4

This Item
U3254SAB4200731C1821
Gene Information

mouse ... Cdh1(12550)

Gene Information

human ... CDH1(999)
mouse ... Cdh1(12550)

Gene Information

human ... CDH1(999)

Gene Information

human ... CDH1(999), CDH2(1000), CDH3(1001)
mouse ... Cdh1(12550), Cdh2(12558), Cdh3(12560)
rat ... Cdh1(83502), Cdh2(83501), Cdh3(116777)

biological source

rat

biological source

rat

biological source

mouse

biological source

mouse

clone

DECMA-1, monoclonal

clone

DECMA-1, monoclonal

clone

CH-19, monoclonal

clone

CH-19, monoclonal

species reactivity

dog, mouse

species reactivity

bovine, human, canine, mouse

species reactivity

guinea pig, canine, frog, bovine, human, cat, monkey, rabbit, mouse, ferret, snake, hamster, chicken, Psammomys (sand rat), rat

species reactivity

canine, frog, snake, guinea pig, chicken, pig, feline, bovine, rabbit, hamster, Psammomys (sand rat), goat, rat, human, sheep, mouse

antibody form

purified immunoglobulin

antibody form

ascites fluid

antibody form

purified from hybridoma cell culture

antibody form

ascites fluid

Still not finding the right product?  

Give our Product Selector Tool a try.

General description

Monoclonal Anti-Uvomorulin/E-Cadherin (rat IgG1 isotype) is derived from the DECMA-1 hybridoma produced by the fusion of rat myeloma cells and splenocytes from an immunized Lou rat. Uvomorulin/E-Cadherin (Epithelial cadherin), also known as CDH1, CAM 120/80, L-CAM (Cell-Adhesion Molecule) or CD324, is a member of the cadherin transmembrane glycoproteins superfamily. It is characterized with a highly conserved cytoplasmic tail.

Immunogen

Mouse embryonal carcinoma cell line PCC4 Aza RI

Application

Monoclonal Anti-Uvomorulin/E-Cadherin antibody produced in rat has been used in various immunochemical techniques including immunoblotting, immunoprecipitation, immunohistochemical staining and immunofluorescent staining.

Biochem/physiol Actions

Cadherins contribute to epithelial cell behavior and tissue morphogenesis/remodeling by facilitating cell-cell adhesion. Monoclonal Anti-Uvomorulin/E-Cadherin can be used for studies of embryonal development, cell-cell interaction of cells grown in culture, and localization of E-Cadherin. In addition, it is commonly used as an E-cadherin inhibitor/blocking antibody in a study of embryonic stem cells (EMS).
E-cadherin is a calcium-dependent glycoprotein. It is responsible for the homogeneous attachment between cells. It suppresses malignant transformation of tumors. Additionally, it also regulates cellular invasion and metastasis.

Physical form

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Storage Class

10 - Combustible liquids

flash_point_f

Not applicable

flash_point_c

Not applicable


Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Documents related to the products that you have purchased in the past have been gathered in the Document Library for your convenience.

Visit the Document Library

Difficulty Finding Your Product Or Lot/Batch Number?

Product numbers are combined with Pack Sizes/Quantity when displayed on the website (example: T1503-25G). Please make sure you enter ONLY the product number in the Product Number field (example: T1503).

Example:

T1503
Product Number
-
25G
Pack Size/Quantity

Additional examples:

705578-5MG-PW

PL860-CGA/SHF-1EA

MMYOMAG-74K-13

1000309185

enter as 1.000309185)

Having trouble? Feel free to contact Technical Service for assistance.

Lot and Batch Numbers can be found on a product's label following the words 'Lot' or 'Batch'.

Aldrich Products

  • For a lot number such as TO09019TO, enter it as 09019TO (without the first two letters 'TO').

  • For a lot number with a filling-code such as 05427ES-021, enter it as 05427ES (without the filling-code '-021').

  • For a lot number with a filling-code such as STBB0728K9, enter it as STBB0728 without the filling-code 'K9'.

Not Finding What You Are Looking For?

In some cases, a COA may not be available online. If your search was unable to find the COA you can request one.

Request COA

Kento Takaya et al.
Scientific reports, 12(1), 15913-15913 (2022-09-24)
Up to a certain developmental stage, a fetus can completely regenerate wounds in the skin. To clarify the mechanism of fetal skin regeneration, identifying when the skin switches from fetal-type wound regeneration to adult-type wound repair is necessary. We hypothesized
Cadherin-mediated cell-cell interactions in normal and cancer cells
Gloushankova NA, et al.
Tissue barriers, 5(3), e1356900-e1356900 (2017)
Yan Zhang et al.
Molecular medicine reports, 12(3), 3393-3399 (2015-05-16)
The aim of the present study was to investigate the expression and clinical significance of hypoxia-inducible factor 1α (HIF-1α), Snail and E-cadherin in ovarian cancer. The expression levels were assessed in a number of ovarian cancer cell lines and ovarian
Adherens and tight junctions: structure, function and connections to the actin cytoskeleton
Hartsock A and Nelson WJ
Biochimica et Biophysica Acta - Biomembranes, 1778(3), 660-669 (2008)
A natural product toosendanin inhibits epithelial-mesenchymal transition and tumor growth in pancreatic cancer via deactivating Akt/mTOR signaling
Pei Z, et al.
Biochemical and Biophysical Research Communications, 493(1), 455-460 (2017)

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service