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SAB4200703

Sigma-Aldrich

Anti-Neurotensin/NTS antibody, Mouse monoclonal

clone NTS-11, purified from hybridoma cell culture

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Synonym(s):
Anti- neurotensin, Anti-NMN125, Anti-NN, Anti-NT, Anti-NT/N

biological source

mouse

Quality Level

conjugate

unconjugated

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

NTS-11, monoclonal

form

buffered aqueous solution

species reactivity

rat, human

concentration

~1 mg/mL

technique(s)

immunoblotting: 5-10 μg/mL using whole extract of SK-N-SH cells
immunohistochemistry: 10-20 μg/mL using heat-retrieved formalin-fixed, paraffin-embedded rat brain sections

isotype

IgG1

UniProt accession no.

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... NTS(4922)
rat ... Nts(299757)

General description

Anti-Neurotensin/NTS antibody, Mouse monoclonal (mouse IgG1 isotype) is derived from the NTS-11 hybridoma, produced by the fusion of mouse myeloma cells and splenocytes from BALB/c mouse immunized with synthetic peptide. Neurotensin (also known as NTS or NT) is a 13 amino acid brain-gut peptide.

Immunogen

Synthetic peptide from C-terminal region of human Neurotensin, conjugated to KLH

Application

Anti-Neurotensin/NTS antibody, Mouse monoclonal has been used in:
  • immunoblotting
  • immunohistochemistry
  • immunofluorescence

Biochem/physiol Actions

Neurotensin (NTS) functions as a neurotransmitter/neuromodulator in the central nervous system (CNS) and as an endocrine agent in the gastrointestinal (GI) tract. Neurotensin is involved in a variety of physiological processes such as, stress and pain modulation, pathophysiology of drug addiction, schizophrenia, Parkinson disease, depression, locomotion and reward. In the brain, neurotensin modulates dopaminergic transmission in the nigrostriatal and mesocorticolimbic pathways as well as hormone secretion from the anterior pituitary.

Physical form

Solution in 0.01 M phosphate buffered saline pH 7.4, containing 15 mM sodium azide

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Storage Class

10 - Combustible liquids

wgk_germany

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable


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