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SAB4200718

Sigma-Aldrich

Anti-Elastin antibody, Mouse monoclonal

clone BA-4, purified from hybridoma cell culture

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Synonym(s):
Anti-ELN, Anti-Tropoelastin
NACRES:
NA.41

biological source

mouse

antibody form

purified from hybridoma cell culture

antibody product type

primary antibodies

clone

BA-4, monoclonal

form

buffered aqueous solution

species reactivity

sheep, hamster, bovine, goat, frog, rabbit, porcine, human, guinea pig, canine

concentration

~1.0 mg/mL

technique(s)

immunoblotting: suitable
immunohistochemistry: 10-20 μg/mL using enzyme-retrieved formalin-fixed, paraffin-embedded sheep arterial tissue sections
immunoprecipitation (IP): suitable

isotype

IgG1

UniProt accession no.

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... EMILIN3(2006)

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E4013V6389A1106
antibody form

purified from hybridoma cell culture

antibody form

ascites fluid

antibody form

purified from hybridoma cell culture

antibody form

purified from hybridoma cell culture

clone

BA-4, monoclonal

clone

BA-4, monoclonal

clone

V9, monoclonal

clone

MAT3-4G10/8, monoclonal

form

buffered aqueous solution

form

-

form

buffered aqueous solution

form

PBS solution

species reactivity

sheep, hamster, bovine, goat, frog, rabbit, porcine, human, guinea pig, canine

species reactivity

human, goat, sheep, guinea pig, pig, canine, feline, bovine

species reactivity

hamster, monkey, dog, horse, bovine, rat, gerbil, chicken, pig, feline, human

species reactivity

human, mouse

concentration

~1.0 mg/mL

concentration

-

concentration

~1 mg/mL

concentration

~2 mg/mL

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General description

Anti-Elastin antibody, Mouse monoclonal (mouse IgG1 isotype) is derived from the BA-4 hybridoma produced by the fusion of mouse myeloma cells and splenocytes from a BALB/c mouse immunized with bovine alpha-Elastin.

Immunogen

bovine alpha-Elastin

Application

Anti-Elastin antibody, Mouse monoclonal has been used in:
  • immunohistochemistry
  • immunoblot
  • immunoprecipitation

Biochem/physiol Actions

Elastin (ELN) provides elasticity and is integrated with other proteins from the ECM in elastic fibrils. Elastin undergoes changes of morphology with aging and at many disease states. In addition, several heritable diseases, such as supravalvular aortic stenosis, cutis laxa, Marfan syndrome, pseudoxanthoma elasticum and Buschke-Ollendorf syndrome, may result from molecular defects of elastin.

Physical form

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Storage Class Code

10 - Combustible liquids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


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Elastin
Biochemistry of Collagens, Laminins and Elastin, 197-201 (2016)
Impaired elastogenesis in Hurler disease: dermatan sulfate accumulation linked to deficiency in elastin-binding protein and elastic fiber assembly
Hinek A and Wilson SE
The American Journal of Pathology, 156(3), 925-938 (2000)
Elastogenesis in human arterial disease: a role for macrophages in disordered elastin synthesis.
Krettek A, et al.
Arteriosclerosis, Thrombosis, and Vascular Biology, 23(4), 582-587 (2003)

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