SAB4300069

Anti-phospho-IGF1R (pTyr¹¹⁶⁵/pTyr¹¹⁶⁶) antibody produced in rabbit

affinity isolated antibody

• Synonym(s): Anti-CD221 antibody produced in rabbit, Anti-IGFIR antibody produced in rabbit, Anti-JTK13 antibody produced in rabbit, Anti-MGC142170 antibody produced in rabbit, Anti-insulin-like growth factor 1 receptor antibody produced in rabbit
• UNSPSC Code: 12352203
• NACRES: NA.41
• MDL number: MFCD00282340
• Conjugate: unconjugated
• Clone: polyclonal
• Application: IF, WB
• Citations: 4

Properties

• biological source: rabbit
• Quality Segment: 100
• conjugate: unconjugated
• antibody form: affinity isolated antibody
• antibody product type: primary antibodies
• clone: polyclonal
• form: buffered aqueous solution
• mol wt: ~200 kDa, ~95 kDa
• species reactivity: rat, mouse, human
• concentration: 1 mg/mL
• technique(s): indirect immunofluorescence: 1:100-1:200, western blot: 1:500-1:1000
• isotype: IgG
• immunogen sequence: (T-D-YP-YP-R-K)
• NCBI accession no.: NP_000866.1
• UniProt accession no.: P08069
• shipped in: wet ice
• storage temp.: −20°C
• target post-translational modification: phosphorylation (pTyr1165/pTyr1166)
• Gene Information: human ... IGF1R(3480)

Description

General description

Insulin like growth factor 1 receptor (IGF1R) is encoded by the gene mapped to human chromosome 15q25- qter. The encoded protein is a transmembrane heterotetramer. It is structurally similar to insulin receptor.

This receptor binds insulin-like growth factor 1 (IGF1) with a high affinity and IGF2 with a lower affinity. It has a tyrosine-protein kinase activity, which is necessary for the activation of the IGF1-stimulated downstream signaling cascade. When present in a hybrid receptor with INSR, binds IGF1.

Immunogen

Peptide sequence around phosphorylation site of tyrosine 1165/tyrosine 1166 (T-D-Y(p)-Y(p)-R-K), according to the protein IGF1R.

Biochem/physiol Actions

Insulin like growth factor 1 receptor (IGF1R) on binding to its ligand, IGF2 regulates cell proliferation and growth. The encoded protein is also facilitates the normal embryonic and postnatal growth. It plays a crucial role in the embryonic growth. Mutations in IGF2 are associated with Silver–Russell syndrome and ring chromosome 15 syndrome. It is upregulated in ovarian cancer.

Features and Benefits

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Physical form

Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Safety Information

• Storage Class: 10 - Combustible liquids
• wgk: WGK 1
• flash_point_f: Not applicable
• flash_point_c: Not applicable