Anti-phospho-MAP2K1 (pSer221) antibody produced in rabbit

affinity isolated antibody

Anti-MEK1 antibody produced in rabbit, Anti-MAPKK1 antibody produced in rabbit, Anti-PRKMK1 antibody produced in rabbit, Anti-MKK1 antibody produced in rabbit, Anti-mitogen-activated protein kinase kinase 1 antibody produced in rabbit
MDL number:

biological source


Quality Level

antibody form

affinity isolated antibody

antibody product type

primary antibodies




buffered aqueous solution

mol wt

~45 kDa

species reactivity

rat, mouse, human


1 mg/mL


immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:50-1:100
indirect immunofluorescence: 1:100-1:200
western blot: 1:500-1:1000



immunogen sequence




NCBI accession no.

UniProt accession no.

shipped in

wet ice

storage temp.


Gene Information

human ... MAP2K1(5604)


Peptide sequence around phosphorylation site of serine 221 (A-N-S(p)-F-V), according to the protein MAP2K1.

Features and Benefits

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Target description

Catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in a Thr-Glu-Tyr sequence located in MAP kinases. Activates ERK1 and ERK2 MAP kinases.

Physical form

Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol


12 - Non Combustible Liquids

WGK Germany


Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificate of Analysis

Certificate of Origin

Yea-Hyun Leem et al.
Neuroscience letters, 580, 163-168 (2014-08-15)
Depression is one of the most prevalent mental illnesses, and causes a constant feeling of sadness and lose of interest, which often leads to suicide. Evidence suggests that depression is associated with aberrant MEK/ERK signaling. However, studies on MEK/ERK signaling...
Minjing Zou et al.
Thyroid : official journal of the American Thyroid Association, 24(8), 1256-1266 (2014-05-07)
RET/PTC rearrangement, RAS, and BRAF mutations are considered to be mutually exclusive in papillary thyroid carcinoma (PTC). However, although concomitant mutations of RET/PTC, RAS, or BRAF have been reported recently, their significance for tumor progression and survival remains unclear. We...
Elena Manara et al.
Blood, 124(2), 263-272 (2014-04-04)
A rare location, t(6;11)(q27;q23) (MLL-AF6), is associated with poor outcome in childhood acute myeloid leukemia (AML). The described mechanism by which MLL-AF6, through constitutive self-association and in cooperation with DOT-1L, activates aberrant gene expression does not explain the biological differences...
Qi Zhang et al.
The Journal of urology, 191(6), 1880-1888 (2014-01-18)
Mutations in the FLCN gene are responsible for fibrofolliculoma, pulmonary and renal cysts, and renal cell carcinoma in patients with Birt-Hogg-Dubé syndrome. To explore therapeutic approaches to renal cell carcinoma in patients with Birt-Hogg-Dubé syndrome we investigated the anticancer effects...
Jessica Tilghman et al.
Cancer research, 74(11), 3168-3179 (2014-04-09)
Glioblastoma (GBM) stem cells (GSC) are a subpopulation of tumor cells that display stem-like characteristics (stemness) and play unique roles in tumor propagation, therapeutic resistance, and tumor recurrence. Therapeutic targets in GSCs are a focus of increasing interest to improve...

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