SAB4300234

Sigma-Aldrich

Anti-phospho-MAP2K1 (pThr291) antibody produced in rabbit

affinity isolated antibody

Synonym(s):
Anti-MEK1 antibody produced in rabbit, Anti-MAPKK1 antibody produced in rabbit, Anti-PRKMK1 antibody produced in rabbit, Anti-MKK1 antibody produced in rabbit, Anti-mitogen-activated protein kinase kinase 1 antibody produced in rabbit
MDL number:
NACRES:
NA.41

biological source

rabbit

Quality Level

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

~45 kDa

species reactivity

human, rat, mouse

concentration

1 mg/mL

application(s)

western blot: 1:500-1:1000

isotype

IgG

immunogen sequence

(P-R-TP-P-G

conjugate

unconjugated

NCBI accession no.

UniProt accession no.

shipped in

wet ice

storage temp.

−20°C

Gene Information

human ... MAP2K1(5604)

Immunogen

Peptide sequence around phosphorylation site of threonine 291 (P-R-T(p)-P-G, according to the protein MAP2K1.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Target description

Catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in a Thr-Glu-Tyr sequence located in MAP kinases. Activates ERK1 and ERK2 MAP kinases.

Physical form

Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol

storage_class_code

12 - Non Combustible Liquids

WGK Germany

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificate of Analysis

Certificate of Origin

Yea-Hyun Leem et al.
Neuroscience letters, 580, 163-168 (2014-08-15)
Depression is one of the most prevalent mental illnesses, and causes a constant feeling of sadness and lose of interest, which often leads to suicide. Evidence suggests that depression is associated with aberrant MEK/ERK signaling. However, studies on MEK/ERK signaling...
Minjing Zou et al.
Thyroid : official journal of the American Thyroid Association, 24(8), 1256-1266 (2014-05-07)
RET/PTC rearrangement, RAS, and BRAF mutations are considered to be mutually exclusive in papillary thyroid carcinoma (PTC). However, although concomitant mutations of RET/PTC, RAS, or BRAF have been reported recently, their significance for tumor progression and survival remains unclear. We...
Elena Manara et al.
Blood, 124(2), 263-272 (2014-04-04)
A rare location, t(6;11)(q27;q23) (MLL-AF6), is associated with poor outcome in childhood acute myeloid leukemia (AML). The described mechanism by which MLL-AF6, through constitutive self-association and in cooperation with DOT-1L, activates aberrant gene expression does not explain the biological differences...
Qi Zhang et al.
The Journal of urology, 191(6), 1880-1888 (2014-01-18)
Mutations in the FLCN gene are responsible for fibrofolliculoma, pulmonary and renal cysts, and renal cell carcinoma in patients with Birt-Hogg-Dubé syndrome. To explore therapeutic approaches to renal cell carcinoma in patients with Birt-Hogg-Dubé syndrome we investigated the anticancer effects...
Jessica Tilghman et al.
Cancer research, 74(11), 3168-3179 (2014-04-09)
Glioblastoma (GBM) stem cells (GSC) are a subpopulation of tumor cells that display stem-like characteristics (stemness) and play unique roles in tumor propagation, therapeutic resistance, and tumor recurrence. Therapeutic targets in GSCs are a focus of increasing interest to improve...

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service