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SAB4300398

Sigma-Aldrich

Anti-MAP3K5 (Ab-83) antibody produced in rabbit

affinity isolated antibody

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Synonym(s):
Anti-ASK1 antibody produced in rabbit, Anti-MAPKKK5 antibody produced in rabbit, Anti-MEKK5 antibody produced in rabbit, Anti-mitogen-activated protein kinase kinase kinase 5 antibody produced in rabbit
MDL number:
NACRES:
NA.41

biological source

rabbit

Quality Level

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

~155 kDa

species reactivity

human

concentration

1 mg/mL

technique(s)

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:50-1:100
indirect immunofluorescence: 1:100-1:200
western blot: 1:500-1:1000

isotype

IgG

immunogen sequence

(G-S-S-V-G)

NCBI accession no.

UniProt accession no.

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... MAP3K5(4217)

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This Item
SAB4300145SAB4300406SAB4300194
conjugate

unconjugated

conjugate

unconjugated

conjugate

unconjugated

conjugate

unconjugated

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

antibody form

affinity isolated antibody

antibody form

affinity isolated antibody

antibody form

affinity isolated antibody

antibody form

affinity isolated antibody

shipped in

wet ice

shipped in

wet ice

shipped in

wet ice

shipped in

wet ice

clone

polyclonal

clone

polyclonal

clone

polyclonal

clone

polyclonal

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Immunogen

Peptide sequence around aa. 81-85 (G-S-S-V-G), according to the protein MAP3K5.

Features and Benefits

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Target description

Component of a protein kinase signal transduction cascade. Phosphorylates and activates MAP2K4 and MAP2K6, which in turn activate the JNK and p38 MAP kinases, respectively. Overexpression induces apoptotic cell death.

Physical form

Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol

Storage Class

10 - Combustible liquids

wgk_germany

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable


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Philipp Grubwieser et al.
Frontiers in cellular and infection microbiology, 12, 875543-875543 (2022-06-07)
Pneumonia is often elicited by bacteria and can be associated with a severe clinical course, respiratory failure and the need for mechanical ventilation. In the alveolus, type-2-alveolar-epithelial-cells (AECII) contribute to innate immune functions. We hypothesized that AECII actively adapt cellular
Alexander Hoffmann et al.
EBioMedicine, 71, 103568-103568 (2021-09-07)
Iron deficiency anaemia (IDA) is a major health concern. However, preventive iron supplementation in regions with high burden of infectious diseases resulted in an increase of infection related morbidity and mortality. We fed male C57BL/6N mice with either an iron
Philipp Grubwieser et al.
Frontiers in microbiology, 14, 1223113-1223113 (2023-08-28)
Klebsiella pneumoniae (KP) is a major cause of hospital-acquired infections, such as pneumonia. Moreover, it is classified as a pathogen of concern due to sprawling anti-microbial resistance. During infection, the gram-negative pathogen is capable of establishing an intracellular niche in
Alina Chakraborty et al.
Genome research, 32(7), 1271-1284 (2022-07-21)
Intronic polyadenylation (IPA) isoforms, which contain alternative last exons, are widely regulated in various biological processes and by many factors. However, little is known about their cytoplasmic regulation and translational status. In this study, we provide the first evidence that

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