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SAB4300499

Sigma-Aldrich

Anti-MAPK14 (Ab-182) antibody produced in rabbit

affinity isolated antibody

Synonym(s):
Anti-CSBP1 antibody produced in rabbit, Anti-CSPB1 antibody produced in rabbit, Anti-EXIP antibody produced in rabbit, Anti-CSBP2 antibody produced in rabbit, Anti-mitogen-activated protein kinase 14 antibody produced in rabbit
NACRES:
NA.41

biological source

rabbit

Quality Level

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

~43 kDa

species reactivity

mouse, human, rat

concentration

1 mg/mL

technique(s)

western blot: 1:500-1:1000

isotype

IgG

immunogen sequence

(T-G-Y-V-A)

NCBI accession no.

UniProt accession no.

shipped in

wet ice

storage temp.

−20°C

Gene Information

human ... MAPK14(1432)

Immunogen

Peptide sequence around aa. 180-184 (T-G-Y-V-A), according to the protein MAPK14.

Features and Benefits

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Target description

Responds to activation by environmental stress, pro-inflammatory cytokines and lipopolysaccharide (LPS) by phosphorylating a number of transcription factors, such as ELK1 and ATF2 and several downstream kinases, such as MAPKAPK2 and MAPKAPK5. Plays a critical role in the production of some cytokines, for example IL-6. May play a role in stabilization of EPO mRNA during hypoxic stress. Isoform Mxi2 activation is stimulated by mitogens and oxidative stress and only poorly phosphorylates ELK1 and ATF2. Isoform Exip may play a role in the early onset of apoptosis.

Physical form

Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol

Storage Class Code

10 - Combustible liquids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificate of Analysis

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Certificate of Origin

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