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Key Documents

SAB4300587

Sigma-Aldrich

Anti-JAK2 (Ab-570) antibody produced in rabbit

affinity isolated antibody

Synonym(s):

Anti-JTK10 antibody produced in rabbit, Anti-Janus kinase 2 (a protein tyrosine kinase) antibody produced in rabbit

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100 μG
$341.00

$341.00

Usually ships in 5 business days. (Orders outside of US, please allow an additional 1-2 weeks for delivery)
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100 μG
$341.00

About This Item

UNSPSC Code:
12352203
NACRES:
NA.43

$341.00

Usually ships in 5 business days. (Orders outside of US, please allow an additional 1-2 weeks for delivery)

biological source

rabbit

Quality Level

100

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

~125 kDa

species reactivity

rat, human

concentration

1 mg/mL

technique(s)

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:50-1:100

isotype

IgG

immunogen sequence

(G-D-Y-G-Q)

NCBI accession no.

NP_004963.1

UniProt accession no.

O60674

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... JAK2(3717)

General description

JAK2 (janus kinase 2) encodes a tyrosine kinase. It belongs to the the Jak family of protein. It is located on chromosome 9p24.

Immunogen

Peptide sequence around aa. 568-572 (G-D-Y-G-Q), according to the protein JAK2.

Biochem/physiol Actions

JAK2 (janus kinase 2) plays an important role in the activities of cytokines receptors. Overexpression of JAK2 results in neuroblastoma. JAK2 mutations promote primary resistance to PD-1 (anti-programmed death protein 1) blockade therapy.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Target description

Plays a role in leptin signaling and control of body weight.

Physical form

Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol

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Storage Class

10 - Combustible liquids

wgk_germany

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
951421522

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Hodgkin's lymphoma cell lines are characterized by frequent aberrations on chromosomes 2p and 9p including REL and JAK2
Joos S, et al.
International Journal of Cancer. Journal International Du Cancer, 103(4), 489-495 (2003)
Cancer-Associated Fibroblasts Share Characteristics and Protumorigenic Activity with Mesenchymal Stromal Cells.
Borriello L
Cancer Research, 77(18), 5142-5157 (2017)
Jak2 is essential for signaling through a variety of cytokine receptors
Parganas E, et al.
Cell, 93(3), 385-395 (1998)
Primary Resistance to PD-1 Blockade Mediated by JAK1/2 Mutations.
Shin DS
Cancer Discovery, 7(2), 188-201 (2017)

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