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SAB4300659

Sigma-Aldrich

Anti-CD10 antibody produced in rabbit

affinity isolated antibody

Synonym(s):

Anti-CALLA, Anti-MGC126681, Anti-MME, Anti-NEP, Anti-SFE

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

biological source

rabbit

Quality Level

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

~100 kDa

species reactivity

human, rat, mouse

concentration

1 mg/mL

technique(s)

western blot: 1:500-1:1000

isotype

IgG

immunogen sequence

(S-Q-M-D-I)

NCBI accession no.

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... CD10(4311)

General description

Cluster of differentiation 10 (CD10) is also known as neprilysin (NEP), that is encoded by MME (membrane metallo-endopeptidase) gene. It has 24 exons and is located on chromosome 3q25.1 to q25.2. It is predominantly expressed in kidney. The protein is made of 742 amino acids with molecular weight of nearly 85 to 110kDa.

The antibody detects endogenous level of total CD10 protein.

Immunogen

Peptide sequence around aa. 6-10 (S-Q-M-D-I), according to the protein NP_000893.2

Biochem/physiol Actions

Cluster of differentiation 10 (CD10) plays an important role in the degeneration of neuropeptides. It participates in several renal diseases. It plays a major role in Alzheimer′s disease. It helps in the degradation of β‐amyloid (Aβ) in the central nervous system (CNS).

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Target description

Thermolysin-like specificity, but is almost confined on acting on polypeptides of up to 30 amino acids. Biologically important in the destruction of opioid peptides such as Met- and Leu-enkephalins by cleavage of a Gly-Phe bond. Able to cleave angiotensin-1, angiotensin-2 and angiotensin 1-9. Involved in the degradation of atrial natriuretic factor (ANF). Displays UV-inducible elastase activity toward skin preelastic and elastic fibers.

Physical form

Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class

10 - Combustible liquids

wgk_germany

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable


Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Mutations in MME cause an autosomal-recessive Charcot-Marie-Tooth disease type 2
Higuchi Y, et al.
Annals of Neurology (2016)

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