Vimentin is a specific type III intermediate filament (IF) protein. It is abundantly expressed in mesenchymal cells. It is located on human chromosome 10p13.
The antibody detects endogenous level of total Vimentin protein.
Peptide sequence around aa. 452-456 (G-Q-V-I-N), according to the protein NP_003371.2
Vimentin helps to preserve the structure of cell and stability of tissue in mesenchymal cells. It is involved in tumorigenesis, EMT (epithelial mesenchymal transition) and the metastatic spread of cancer. It also controls infectious internalization of human papillomavirus 16 pseudovirions.
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Vimentins are class-III intermediate filaments found in various non-epithelial cells, especially mesenchymal cells.
Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol
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