SAB4300676

Sigma-Aldrich

Anti-Vimentin antibody produced in rabbit

affinity isolated antibody

Synonym(s):
Anti-FLJ36605, Anti-VIM
NACRES:
NA.41
Pricing and availability is not currently available.

biological source

rabbit

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

~57 kDa

species reactivity

mouse, human, rat, monkey

concentration

1 mg/mL

application(s)

western blot: 1:500-1:1000

isotype

IgG

immunogen sequence

(G-Q-V-I-N)

conjugate

unconjugated

NCBI accession no.

shipped in

wet ice

storage temp.

−20°C

Gene Information

human ... Vimentin(7431)

General description

Vimentin is a specific type III intermediate filament (IF) protein. It is abundantly expressed in mesenchymal cells. It is located on human chromosome 10p13.

The antibody detects endogenous level of total Vimentin protein.

Immunogen

Peptide sequence around aa. 452-456 (G-Q-V-I-N), according to the protein NP_003371.2

Biochem/physiol Actions

Vimentin helps to preserve the structure of cell and stability of tissue in mesenchymal cells. It is involved in tumorigenesis, EMT (epithelial mesenchymal transition) and the metastatic spread of cancer. It also controls infectious internalization of human papillomavirus 16 pseudovirions.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Target description

Vimentins are class-III intermediate filaments found in various non-epithelial cells, especially mesenchymal cells.

Physical form

Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

RIDADR

NONH for all modes of transport

WGK Germany

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificate of Analysis
Certificate of Origin
Viscoelastic properties of vimentin compared with other filamentous biopolymer networks
Janmey PA, et al.
The Journal of Cell Biology (1991)
Vimentin is a potential prognostic factor for tongue squamous cell carcinoma among five epithelial-mesenchymal transition-related proteins
Liu PF, et al.
PLoS ONE (2017)
The gene encoding human vimentin is located on the short arm of chromosome 10
Ferrari S, et al.
American Journal of Human Genetics (1987)
Vimentin Modulates Infectious Internalization of Human Papillomavirus 16 Pseudovirions
Schafer G, et al.
Journal of Virology (2017)
Toshifumi Murai et al.
Journal of surgical oncology, 109(7), 684-689 (2014-01-24)
Epithelial-to-mesenchymal transition (EMT) is considered to play an important role in cancer invasion and metastasis. The mRNA levels of an epithelial marker (E-cadherin), mesenchymal marker (vimentin), and Zeb-1 were measured in 11 gastric cancer cell lines. Functional analysis was performed...

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