Anti-MKP1 Antibody detects endogenous levels of total MKP1 protein.
MKP1 (mitogen-activated protein kinase phosphatase 1)/DUSP1 (dual specificity phosphatase 1) is a dual specificity phosphatase. It is also called as CL100, 3CH134 and Erp. MKP1 is located in the nucleus and is expressed in several tissues. It is located on human chromosome 5q35.
Immunogen
The antiserum was produced against synthesized peptide derived from human MKP1.
Immunogen Range: 318-367
Biochem/physiol Actions
In mast cells, MKP1 (mitogen-activated protein kinase phosphatase 1) blocks the functions of extracellular signal-regulated kinase (Erk)‐1/2 by glucocorticoid. It controls axon branching promoted by BDNF (brain-derived neurotrophic factor).
Features and Benefits
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Physical form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Conditional expression of the mitogen-activated protein kinase (MAPK) phosphatase MKP-1 preferentially inhibits p38 MAPK and stress-activated protein kinase in U937 cells
Franklin CC and Kraft AS
The Journal of Biological Chemistry, 272(27), 272(27)-272(27) (1997)
Glucocorticoids inhibit MAP kinase via increased expression and decreased degradation of MKP-1
Kassel O, et al.
The Embo Journal, 20(24), 7108-7116 (2001)
The MAP kinase phosphatase MKP-1 regulates BDNF-induced axon branching
The Journal of biological chemistry, 271(11), 6497-6501 (1996-03-15)
Mitogen-activated protein (MAP) kinases can be grouped into three structural families, ERK, JNK, and p38, which are thought to carry out unique functions within cells. We demonstrate that ERK, JNK, and p38 are activated by distinct combinations of stimuli in
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