SAB4501719

Sigma-Aldrich

Anti-LAMA4 antibody produced in rabbit

affinity isolated antibody

Synonym(s):
Laminin subunit α-4, LAMA4
NACRES:
NA.41

biological source

rabbit

Quality Level

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen 202 kDa

species reactivity

human, mouse

concentration

~1 mg/mL

application(s)

ELISA: 1:40000
immunofluorescence: 1:100-1:500
immunohistochemistry: 1:50-1:100
western blot: 1:500-1:1000

conjugate

unconjugated

NCBI accession no.

UniProt accession no.

shipped in

wet ice

storage temp.

−20°C

Gene Information

human ... LAMA4(3910)

General description

Anti-LAMA4 Antibody detects endogenous levels of total LAMA4 protein.
Laminin-A4 (LAMA4) is a protein that is expressed at high levels in vivo in clusters of hypertrophic chondrocytes. It is located on human chromosome 6q21.

Immunogen

The antiserum was produced against synthesized peptide derived from human LAMA4.

Immunogen Range: 481-530

Application

Anti-LAMA4 antibody has been used in western blotting, immunohistochemistry and immunocytochemistry.

Biochem/physiol Actions

Laminin-A4 (LAMA4) decreases the amount of cellular protrusions in cultured human chondrocytes. It participates in migration, proliferation and survival of several cells. LAMA4 induces invasion, migration and angiogenesis of trophoblast cell.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Physical form

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

storage_class_code

12 - Non Combustible Liquids

WGK Germany

nwg

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificate of Analysis

Certificate of Origin

The laminin family.
Aumailley M.
Cell adhesion & migration, 7(1), 48-55 (2013)
N Shan et al.
Placenta, 36(8), 809-820 (2015-06-11)
The laminin α4 subunit (LAMA4) has been shown to promote migration, proliferation, and survival of various cell types. This study investigated LAMA4's role in trophoblast cells during placental development. LAMA4 expression was immunohistochemically assessed in the first trimester and term...
Effect of Laminin?A4 inhibition on cluster formation of human osteoarthritic chondrocytes.
Moazedi?Fuerst FC, et al.
Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society, 34(3), 419-426 (2016)
Laminin α4 (LAMA4) expression promotes trophoblast cell invasion, migration, and angiogenesis, and is lowered in preeclamptic placentas.
Shan N, et al,
Placenta, 36(8), 809?820-809?820 (2015)
Jyoti Gautam et al.
Scientific reports, 6, 36450-36450 (2016-11-04)
Laminin, a major component of the basement membrane, plays an important role in blood brain barrier regulation. At the neurovascular unit, brain endothelial cells, astrocytes, and pericytes synthesize and deposit different laminin isoforms into the basement membrane. It has been...

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