SAB4501821

Sigma-Aldrich

Anti-TAU antibody produced in rabbit

affinity isolated antibody

Synonym(s):
Microtubule-associated protein tau, Paired helical filament-tau, Neurofibrillary tangle protein, MTBT1, MAPT
MDL number:

biological source

rabbit

Quality Level

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen 78 kDa

species reactivity

mouse, rat, human

concentration

~1 mg/mL

application(s)

ELISA: 1:20000
western blot: 1:500-1:1000

conjugate

unconjugated

NCBI accession no.

UniProt accession no.

shipped in

wet ice

storage temp.

−20°C

Gene Information

human ... MAPT(4137)

General description

Anti-TAU antibody detects endogenous levels of total TAU protein.
MAPT (microtubule associated protein tau) is located on human chromosome 17q21.3. It is expressed in neurons but is most prominent in axons.

Immunogen

The antiserum was produced against synthesized peptide derived from human Tau.

Immunogen Range: 501-550

Biochem/physiol Actions

Removal of MAPT results in developmental delay and learning disability. It participates in the pathology of Alzheimer′s disease (AD). It helps in the assembly and maintenance of microtubule structure.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Physical form

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

storage_class_code

12 - Non Combustible Liquids

WGK Germany

nwg

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificate of Analysis

Certificate of Origin

Youssra K Al-Hilaly et al.
FEBS letters, 594(5), 944-950 (2019-11-14)
The constituent paired helical filaments (PHFs) in neurofibrillary tangles are insoluble intracellular deposits central to the development of Alzheimer's disease (AD) and other tauopathies. Full-length tau requires the addition of anionic cofactors such as heparin to enhance assembly. We have...
Robert Prucek et al.
Scientific reports, 11(1), 6240-6240 (2021-03-20)
Targeted and effective therapy of diseases demands utilization of rapid methods of identification of the given markers. Surface enhanced Raman spectroscopy (SERS) in conjunction with streptavidin-biotin complex is a promising alternative to culture or PCR based methods used for such...
Microdeletion encompassing MAPT at chromosome 17q21.3 is associated with developmental delay and learning disability
Shaw-Smith C
Nature Genetics, 38(9), 1032-1037 (2006)
The H1c haplotype at the MAPT locus is associated with Alzheimer's disease
Myers AJ, et al.
Human Molecular Genetics, 14(16), 2399-2404 (2005)
Linkage disequilibrium and association of MAPT H1 in Parkinson disease
Skipper L, et al.
American Journal of Human Genetics, 75(4), 669-677 (2004)

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