MilliporeSigma
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SAB4501984

Sigma-Aldrich

Anti-NRF2 antibody produced in rabbit

affinity isolated antibody

Synonym(s):
HEBP1, NF-E2 related factor 2, NF2L2, NFE2-related factor 2, NFE2L2
NACRES:
NA.41

biological source

rabbit

Quality Level

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen 67 kDa

species reactivity

rat, mouse, human

concentration

~1 mg/mL

technique(s)

ELISA: 1:5000
immunofluorescence: 1:100-1:500
immunohistochemistry: 1:50-1:100
western blot: 1:500-1:1000

NCBI accession no.

UniProt accession no.

shipped in

wet ice

storage temp.

−20°C

Gene Information

human ... NFE2L2(4780)

General description

Anti-NRF2 Antibody detects endogenous levels of total NRF2 protein.
NRF2 (nuclear factor, erythroid 2 like 2) gene is mapped to human chromosome 2q31.2.[1] The encoded protein is localized to dendritic cells.[2] It belongs to the cap ′n′ collar (CNC) family of transcription factors.[3]

Immunogen

The antiserum was produced against synthesized peptide derived from human Nrf2.

Immunogen Range: 556-605

Application

Anti-NRF2, C-Terminal antibody produced in rabbit has been used in western blotting analysis.[4][5]

Biochem/physiol Actions

Nrf2 (nuclear factor, erythroid 2 like 2) is involved in the regulation of anti-oxidative and anti-inflammatory response. The protein encoded is a transcription factor that binds to the antioxidant response element of the target gene. In response to oxidative stress, Nrf2 upregulates the enzymes associated with detoxification, anti-inflammation, cytoprotection and antioxidative pathways.[6] Nrf2 affects glucose metabolism and ROS (reactive oxygen species) homeostasis in cancer cells by regulating the pentose phosphate pathway. Thus, Nrf2 is known to contribute to the development of cancer by promoting cell proliferation.[7]

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Physical form

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Storage Class Code

12 - Non Combustible Liquids

WGK

nwg

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificate of Analysis

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Certificate of Origin

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