SAB4501990

Anti-NF-κB p105 antibody produced in rabbit

affinity isolated antibody

• Synonym(s): DNA-binding factor KBF1, EBP-1, NF-κ-B1 p84/NF-κ-B1 p98, NFKB1, NFkB-p50
• NACRES: NA.41

Properties

• biological source: rabbit
• Quality Level: 100
• conjugate: unconjugated
• antibody form: affinity isolated antibody
• antibody product type: primary antibodies
• clone: polyclonal
• form: buffered aqueous solution
• mol wt: antigen 105 kDa
• species reactivity: human
• concentration: ~1 mg/mL
• technique(s): ELISA: 1:20000; immunohistochemistry: 1:50-1:100; western blot: 1:500-1:1000
• NCBI accession no.: P19838
• UniProt accession no.: P19838
• shipped in: wet ice
• storage temp.: −20°C
• Gene Information: human ... NFKB1(4790)

Description

General description

Anti-NF-κB p105 Antibody detects endogenous levels of total NF-κB p105 protein.

The gene NFκB1(nuclear factor κ B subunit 1) is mapped to human chromosome 4q24. It codes for κB p105/p50 isoforms.

Immunogen

The antiserum was produced against synthesized peptide derived from human NF-kappaB p105/p50.

Immunogen Range: 860-909

Biochem/physiol Actions

NF-κB (nuclear factor κ B) is an important transcription factor that regulates the process of apoptosis, immune response and cell-growth control genes. It is associated with a number of human disorders including inflammatory diseases and cancers. NF-κB signaling cascade is known to be stimulated by many genotoxic stresses and also DNA damage. NF-κB is involved in bone metabolism. Downregulation of NF-κB mediates GPER (G-protein coupled estrogen receptor) specific agonist G-1 induced EMT (epithelial mesenchymal transition) suppression. Thereby, it prevents the motility of triple-negative breast cancer cells in vitro.

Features and Benefits

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Physical form

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Safety Information

• Storage Class Code: 12 - Non Combustible Liquids
• WGK: nwg
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable