SAB4502055
Anti-OVOL1 antibody produced in rabbit
affinity isolated antibody
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Synonym(s):
OVOL1, Putative transcription factor Ovo-like 1, hOvo1
UNSPSC Code:
12352203
NACRES:
NA.41
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biological source
rabbit
Quality Level
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen 30 kDa
species reactivity
human, mouse
concentration
~1 mg/mL
technique(s)
ELISA: 1:40000
western blot: 1:500-1:1000
NCBI accession no.
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... OVOL1(5017)
General description
Anti-OVOL1 antibody detects endogenous levels of total OVOL1 protein.
The OVOL1 (ovo like transcriptional repressor 1) gene is mapped to human chromosome 11q13.1. It is widely conserved. In mammals, the gene encodes for C2H2 zinc finger transcription factor. It is predominantly expressed in the human placenta and in the inner root sheath of the hair follicle, suprabasal layer of the epidermis, the ductal portion of the eccrine glands and mature sebocytes of the skin.{36] The protein is localized to cytoplasm.
Immunogen
The antiserum was produced against synthesized peptide derived from human OVOL1.
Immunogen Range: 1-50
Immunogen Range: 1-50
Biochem/physiol Actions
The protein encoded by the OVOL1 (ovo like transcriptional repressor 1) gene regulates proliferation and differentiation of epithelial cells. This protein is homologous to that in Drosophila species, which regulates trophoblast differentiation. OVOL1 is known to take part in epidermal keratinisation by inducing differentiation. OVOL1 is associated with atopic dermatitis. OVOL1 is associated with skin morphogenesis and tumorigenesis.
Features and Benefits
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Physical form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
wgk_germany
nwg
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificates of Analysis (COA)
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Activation of the OVOL1-OVOL2 Axis in the Hair Bulb and in Pilomatricoma.
Ito T
The American Journal of Pathology, 186(4), 1036-1043 (2016)
OVO-like 1 regulates progenitor cell fate in human trophoblast development.
Renaud SJ
Proceedings of the National Academy of Sciences of the USA, 112(45), E6175-E6184 (2015)
Chikage Mitoma et al.
Fukuoka igaku zasshi = Hukuoka acta medica, 105(8), 166-173 (2014-12-17)
OVOL1 is an important transcription factor for epidermal keratinization, which suppresses proliferation and switches on the differentiation of keratinocytes. A recent genome-wide association study has revealed that OVOL1 is one of the genes associated with susceptibility to atopic dermatitis. Although
High density genotyping study identifies four new susceptibility loci for atopic dermatitis
David Ellinghaus
Nature Genetics, 45(7), 808-812 (2013)
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