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SAB4502136

Sigma-Aldrich

Anti-PDGFB antibody produced in rabbit

affinity isolated antibody

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Synonym(s):
PDGF subunit B, PDGF-2, Platelet-derived growth factor β polypeptide, Platelet-derived growth factor B chain, Platelet-derived growth factor subunit B
NACRES:
NA.41

biological source

rabbit

Quality Level

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen 27 kDa

species reactivity

mouse, human, rat

concentration

~1 mg/mL

technique(s)

ELISA: 1:10000
western blot: 1:500-1:1000

NCBI accession no.

UniProt accession no.

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... PDGFB(5155)

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This Item
HPA046183HPA028499HPA009134
antibody form

affinity isolated antibody

antibody form

affinity isolated antibody

antibody form

affinity isolated antibody

antibody form

affinity isolated antibody

biological source

rabbit

biological source

rabbit

biological source

rabbit

biological source

rabbit

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

UniProt accession no.

P01127

UniProt accession no.

Q9GZP0

UniProt accession no.

P09619

UniProt accession no.

Q9NRA1

Gene Information

human ... PDGFB(5155)

Gene Information

human ... PDGFD(80310)

Gene Information

human ... PDGFRB(5159)

Gene Information

human ... PDGFC(56034)

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General description

Anti-PDGFB Antibody detects endogenous levels of total PDGFB protein.
The platelet derived growth factor receptor β (PDGFRB) gene is mapped to human chromosome 5q32. It encodes for a receptor tyrosine kinase.

Immunogen

The antiserum was produced against synthesized peptide derived from human PDGFB.

Immunogen Range: 16-65

Biochem/physiol Actions

Platelet derived growth factor receptor β (PDGFRB) acts as a regulator of mesenchymal cells in tumor cells. Upregulation of the gene is observed in gastric cancer, breast and prostate cancers. Mutations in the gene is associated with infantile myofibromatosis.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Physical form

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Storage Class

10 - Combustible liquids

wgk_germany

nwg

flash_point_f

Not applicable

flash_point_c

Not applicable


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A genome-wide map of aberrantly expressed chromosomal islands in colorectal cancer.
Staub E, et al.
Molecular Cancer, 5(1), 37-37 (2006)
Yanyu Zhang et al.
Cancers, 14(8) (2022-04-24)
Platelets constitute a major reservoir of platelet-derived growth factor B (PDGFB) and are continuously activated in the tumor microenvironment, exposing tumors to the plethora of growth factors contained in platelet granules. To address the specific role of platelet-derived PDGFB in
PDGFRB gain-of-function mutations in sporadic infantile myofibromatosis.
Arts FA
Human Molecular Genetics, 26(10), 1801-1810 (2017)
Quantitative proteomic analysis of gastric cancer tissue reveals novel proteins in platelet-derived growth factor b signaling pathway.
Liu F
Oncotarget, 8(13), 22059-22075 (2017)

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