Immunoglobulin Y is one of the antibodies produced in birds. It is generally related to mammalian IgG. However, IgY has different characteristics compared to mammalian IgG, for example, IgY does not bind with mammalian complements nor Rheumatoid factor, which are present in mammalian serum and anti-mammalian IgG antibodies, which often cross-react to IgG from different mammalian species, exhibit low cross-reactivity to IgY. These characteristics of IgY is beneficial when it is used as a biochemical/clinical reagent. Immunoglobulin Y, present in chicken blood serum, has the capability to pass across the follicular epithelium of the ovary and aggregate in the yolk during oogenesis. Structurally IgY and mammalian IgG differ in the heavy chain with the molecular weight of 68,000 and 50,000 respectively. Mammalian IgG has slightly higher stability compared to IgY.
CF™488A is a green fluorescent dye with excitation argon laser line at 488 nm. CF™488A is minimally charged, thus it reduces non-specific binding of antibody conjugates. CF™488A is a highly water-soluble and pH-insensitive dye with molecular weight of ~710. This dye has absorption/emission maxima at 490/515 nm and it is highly photostable.
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