SAB4700458

Monoclonal Anti-CD140b antibody produced in mouse

Name: Monoclonal Anti-CD140b antibody produced in mouse
Brand: SIGMA
Price: 311 USD

clone 18A2, purified immunoglobulin, buffered aqueous solution

Synonym(s):

Anti-PDGF-RB, Anti-PDGFRB

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100 μG

$311.00

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About This Item

UNSPSC Code:

12352203

NACRES:

NA.41

Key Documents

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biological source

mouse

Quality Level

100

conjugate

unconjugated

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

18A2, monoclonal

form

buffered aqueous solution

species reactivity

human

concentration

1 mg/mL

technique(s)

flow cytometry: suitable

isotype

IgG1

NCBI accession no.

NM_002609.3

UniProt accession no.

P09619

shipped in

wet ice

storage temp.

2-8°C

target post-translational modification

unmodified

Gene Information

human ... PDGFRB(5159)

Related Categories

Antibodies by Application

Flow Cytometry Antibodies

Primary Antibodies

Protein Biology

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Show Differences

1 of 4

This Item	SAB4700459	SAB1305510	SAB4502148
Sigma-Aldrich SAB4700458 Monoclonal Anti-CD140b antibody produced in mouse	Sigma-Aldrich SAB4700459 Monoclonal Anti-CD140b-APC antibody produced in mouse	Sigma-Aldrich SAB1305510 MONOCLONAL ANTI-PDGFR antibody produced in mouse	Sigma-Aldrich SAB4502148 Anti-PDGFR β antibody produced in rabbit
species reactivity human	species reactivity human	species reactivity mouse	species reactivity mouse, human, rat
Gene Information human ... PDGFRB(5159)	Gene Information human ... PDGFRB(5159)	Gene Information human ... PDGFRB(5159)	Gene Information human ... PDGFRB(5159)
clone 18A2, monoclonal	clone 18A2, monoclonal	clone 275CT1, monoclonal	clone polyclonal
conjugate unconjugated	conjugate Allophycocyanin conjugate	conjugate -	conjugate unconjugated
biological source mouse	biological source mouse	biological source mouse	biological source rabbit
antibody form purified immunoglobulin	antibody form purified immunoglobulin	antibody form crude ascites	antibody form affinity isolated antibody

General description

The monoclonal antibody 18A2 recognizes CD140b / PDGF-RB, the 180-190 kDa beta chain of platelet-derived growth factor receptor, which is widely expressed on a variety of mesenchymal-derived cells and plays pro-proliferative roles.

Immunogen

CD140b-transfected NIH 3T3 cells

Application

The reagent is designed for Flow Cytometry analysis. Suggested working dilution for Flow Cytometry is 1-5 μg/mL of sample. Indicated dilution is recommended starting point for use of this product. Working concentrations should be determined by the investigator.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Physical form

Solution in phosphate buffered saline, pH 7.4, with 15 mM sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class

10 - Combustible liquids

flash_point_f

Not applicable

flash_point_c

Not applicable

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A vasculature niche orchestrates stromal cell phenotype through PDGF signaling: Importance in human fibrotic disease.

Thomas B Layton et al.

Proceedings of the National Academy of Sciences of the United States of America, 119(13), e2120336119-e2120336119 (2022-03-24)

SignificanceTissue fibrotic diseases, for example of the liver and lung, represent a huge unmet medical need. In this study, using single-cell RNA sequencing, cytometry by time of flight (CyTOF), tissue imaging, and functional assays, we identify a complex vascular niche

Cellular census of human fibrosis defines functionally distinct stromal cell types and states.

Thomas B Layton et al.

Nature communications, 11(1), 2768-2768 (2020-06-04)

Fibrotic disorders are some of the most devastating and poorly treated conditions in developed nations, yet effective therapeutics are not identified for many of them. A major barrier for the identification of targets and successful clinical translation is a limited

Loss of the transcription factor RBPJ induces disease-promoting properties in brain pericytes.

Rodrigo Diéguez-Hurtado et al.

Nature communications, 10(1), 2817-2817 (2019-06-30)

Sufficient vascular supply is indispensable for brain development and function, whereas dysfunctional blood vessels are associated with human diseases such as vascular malformations, stroke or neurodegeneration. Pericytes are capillary-associated mesenchymal cells that limit vascular permeability and protect the brain by

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