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SAB4700458

Sigma-Aldrich

Monoclonal Anti-CD140b antibody produced in mouse

clone 18A2, purified immunoglobulin, buffered aqueous solution

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Synonym(s):
Anti-PDGF-RB, Anti-PDGFRB
NACRES:
NA.41

biological source

mouse

Quality Level

conjugate

unconjugated

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

18A2, monoclonal

form

buffered aqueous solution

species reactivity

human

concentration

1 mg/mL

technique(s)

flow cytometry: suitable

isotype

IgG1

NCBI accession no.

UniProt accession no.

shipped in

wet ice

storage temp.

2-8°C

target post-translational modification

unmodified

Gene Information

human ... PDGFRB(5159)

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SAB4700459SAB4700460SAB1305510
clone

18A2, monoclonal

clone

18A2, monoclonal

clone

18A2, monoclonal

clone

275CT1, monoclonal

species reactivity

human

species reactivity

human

species reactivity

human

species reactivity

mouse

Gene Information

human ... PDGFRB(5159)

Gene Information

human ... PDGFRB(5159)

Gene Information

human ... PDGFRB(5159)

Gene Information

human ... PDGFRB(5159)

biological source

mouse

biological source

mouse

biological source

mouse

biological source

mouse

conjugate

unconjugated

conjugate

Allophycocyanin conjugate

conjugate

phycoerythrin (R-PE) conjugate

conjugate

-

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General description

The monoclonal antibody 18A2 recognizes CD140b / PDGF-RB, the 180-190 kDa beta chain of platelet-derived growth factor receptor, which is widely expressed on a variety of mesenchymal-derived cells and plays pro-proliferative roles.

Immunogen

CD140b-transfected NIH 3T3 cells

Application

The reagent is designed for Flow Cytometry analysis. Suggested working dilution for Flow Cytometry is 1-5 μg/mL of sample. Indicated dilution is recommended starting point for use of this product. Working concentrations should be determined by the investigator.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Physical form

Solution in phosphate buffered saline, pH 7.4, with 15 mM sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Storage Class

10 - Combustible liquids

flash_point_f

Not applicable

flash_point_c

Not applicable


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Thomas B Layton et al.
Proceedings of the National Academy of Sciences of the United States of America, 119(13), e2120336119-e2120336119 (2022-03-24)
SignificanceTissue fibrotic diseases, for example of the liver and lung, represent a huge unmet medical need. In this study, using single-cell RNA sequencing, cytometry by time of flight (CyTOF), tissue imaging, and functional assays, we identify a complex vascular niche
Thomas B Layton et al.
Nature communications, 11(1), 2768-2768 (2020-06-04)
Fibrotic disorders are some of the most devastating and poorly treated conditions in developed nations, yet effective therapeutics are not identified for many of them. A major barrier for the identification of targets and successful clinical translation is a limited
Rodrigo Diéguez-Hurtado et al.
Nature communications, 10(1), 2817-2817 (2019-06-30)
Sufficient vascular supply is indispensable for brain development and function, whereas dysfunctional blood vessels are associated with human diseases such as vascular malformations, stroke or neurodegeneration. Pericytes are capillary-associated mesenchymal cells that limit vascular permeability and protect the brain by

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