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SAB4700520

Sigma-Aldrich

Monoclonal Anti-CD71 antibody produced in mouse

clone MEM-189, purified immunoglobulin, buffered aqueous solution

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Synonym(s):
Anti-TFRC, Anti-Transferrin Receptor
NACRES:
NA.41

biological source

mouse

Quality Level

conjugate

unconjugated

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

MEM-189, monoclonal

form

buffered aqueous solution

species reactivity

human

concentration

1 mg/mL

technique(s)

flow cytometry: suitable

isotype

IgG1

NCBI accession no.

UniProt accession no.

shipped in

wet ice

storage temp.

2-8°C

target post-translational modification

unmodified

Gene Information

human ... TFRC(7037)

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This Item
WH0000999M1SAB4700223SAB4700863
clone

MEM-189, monoclonal

clone

3F4, monoclonal

clone

3F3, monoclonal

clone

AD2, monoclonal

species reactivity

human

species reactivity

human

species reactivity

human

species reactivity

human

conjugate

unconjugated

conjugate

unconjugated

conjugate

unconjugated

conjugate

unconjugated

Gene Information

human ... TFRC(7037)

Gene Information

human ... CDH1(999)

Gene Information

human ... CD72(971)

Gene Information

human ... NT5E(4907)

antibody form

purified immunoglobulin

antibody form

purified immunoglobulin

antibody form

purified immunoglobulin

antibody form

purified immunoglobulin

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General description

Cluster of differentiation 71 (CD71), also known as transferrin receptor, is encoded by the gene mapped to human chromosome 3q29. CD71 is present on cells with high proliferation.
The antibody MEM-189 reacts with CD71 antigen (transferrin receptor), a 95 kDa type II homodimeric transmembrane glycoprotein expressed on activated B and lymphocytes, macrophages and erythroid precursors; it is lost on resting blood leukocytes.

Immunogen

KG1 human acute myelogenous leukaemia cell line

Application

The reagent is designed for Flow Cytometry analysis. Suggested working dilution for Flow Cytometry is 2 μg/mL of sample. Indicated dilution is recommended starting point for use of this product. Working concentrations should be determined by the investigator.

Biochem/physiol Actions

Cluster of differentiation 71 (CD71) functions as an iron regulatory protein. Overexpression of the gene has been associated with the development of various types of cancers, including cholangiocarcinoma (CCA). Thus, CD71 protein is considered as a potential therapeutic target for CCA and iron overload. The encoded protein facilitates mitochondrial respiration and reactive oxygen species (ROS) production in human pancreatic ductal adenocarcinoma (PDAC) cells, which is essential for their tumorigenic growth. Thus, aberrant expression of CD71 might also lead to the development of pancreatic cancer.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Physical form

Solution in Tris buffered saline, pH 8.0, with 15 mM sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Storage Class

12 - Non Combustible Liquids

wgk_germany

nwg

flash_point_f

Not applicable

flash_point_c

Not applicable


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Upregulation of transferrin receptor-1 induces cholangiocarcinoma progression via induction of labile iron pool
Jamnongkan W
Tumour Biology : the Journal of the International Society For Oncodevelopmental Biology and Medicine, 39 (2017)
Transferrin receptor (CD71) is a marker of poor prognosis in breast cancer and can predict response to tamoxifen
Habashy HO
Breast Cancer Research and Treatment, 119, 283-293 (2010)
Transferrin receptor regulates pancreatic cancer growth by modulating mitochondrial respiration and ROS generation.
Jeong SM
Biochemical and Biophysical Research Communications, 471, 373-379 (2016)
NotI linking/jumping clones of human chromosome 3: mapping of the TFRC, RAB7 and HAUSP genes to regions rearranged in leukemia and deleted in solid tumors.
Kashuba VI
Febs Letters, 419, 181-185 (1997)

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