SAB4702023

Monoclonal Anti-CD23 PE-Cyanine7 produced in mouse

• Synonym(s): BLAST-2, CLEC4J, FCE2, FCER2, Fc-epsilon-RII, IGEBF
• UNSPSC Code: 12352203

Properties

• conjugate: PE-Cy7 conjugate
• Quality Level: 100
• antibody product type: primary antibodies
• clone: EBVCS-5, monoclonal
• form: buffered aqueous solution
• species reactivity: human
• technique(s): flow cytometry: suitable
• isotype: IgG1κ
• UniProt accession no.: P06734
• storage temp.: 2-8°C
• target post-translational modification: unmodified
• Gene Information: human ... FCER2(2208)

Description

General description

CD23 (Fc epsilon RII), the low affinity IgE receptor, is a 45 kDa type II membrane glycoprotein expressed more or less on eosinophils, follicular dendritic cells, Langerhans cells, mature B cells (mainly upon activation), EBV-transformed lymphoblasts, monocytes, and subpopulation of platelets. A soluble form of 37 kDa and other its fragments were also described. CD23 mediates IgE-dependent cytotoxicity by eosinophils and macrophages, and downregulates IgE secretion in response to high levels of IgE, involving release of pro-inflammatory cytokines.

Immunogen

EBV-transformed human cells

Biochem/physiol Actions

The mouse monoclonal antibody EBVCS-5 recognizes an extracellular epitope located in the stalk region of human low affinity IgE receptor (CD23) between the 37 and 25 kDa cleavage sites.

Physical form

Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide

Preparation Note

Purified antibody is conjugated with activated tandem dye of R-phycoerythrin-cyanine 7 (PE-Cy7) under optimum conditions and unconjugated antibody and free fluorochrome are removed by size-exclusion chromatography.

Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.

Other Notes

The antibody solution should be gently mixed before use.

Safety Information

• Storage Class: 12 - Non Combustible Liquids
• wgk_germany: WGK 1
• flash_point_f: Not applicable
• flash_point_c: Not applicable