SAB5200112

Anti-Aquaporin-4 Antibody

Name: Anti-Aquaporin-4 Antibody
Brand: SIGMA
Price: 580 USD

rabbit polyclonal

Synonym(s):

Anti-AQP4, Anti-Aquaporin 4

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100 μL

$580.00

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About This Item

UNSPSC Code:

12352203

NACRES:

NA.41

Conjugate:

unconjugated

Clone:

polyclonal

Application:

IF, WB

Citations:

Key Documents

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Product Name

Anti-AQP4 antibody produced in rabbit, 1 mg/mL, affinity isolated antibody

biological source

rabbit

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous glycerol solution

mol wt

antigen predicted mol wt 35 kDa

species reactivity

rat, human, mouse

concentration

1 mg/mL

technique(s)

indirect immunofluorescence: suitable, western blot: suitable

NCBI accession no.

NP_036957.1

UniProt accession no.

P55087

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Quality Level

100

Gene Information

rat ... Aqp4(25293)

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Primary Antibodies

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Show Differences

1 of 4

This Item	SAB5200110	HPA046259	HPA065008
Sigma-Aldrich SAB5200112 Anti-AQP4 antibody produced in rabbit	Sigma-Aldrich SAB5200110 Anti-AQP2 antibody produced in rabbit	Sigma-Aldrich HPA046259 Anti-AQP8 antibody produced in rabbit	Sigma-Aldrich HPA065008 Anti-AQP5 antibody produced in rabbit
antibody form affinity isolated antibody	antibody form affinity isolated antibody	antibody form affinity isolated antibody	antibody form affinity isolated antibody
conjugate unconjugated	conjugate unconjugated	conjugate unconjugated	conjugate unconjugated
Quality Level 100	Quality Level 100	Quality Level 100	Quality Level 100
biological source rabbit	biological source rabbit	biological source rabbit	biological source rabbit
Gene Information rat ... Aqp4(25293)	Gene Information rat ... Aqp2(25386)	Gene Information human ... AQP8(343)	Gene Information human ... AQP5(362)
species reactivity rat, human, mouse	species reactivity human, mouse, rat	species reactivity human	species reactivity human

General description

Aquaporin 4 (AQP4) is expressed in the nervous system. The gene ID of the protein is 25293.

Immunogen

C-terminal peptide

Biochem/physiol Actions

Aquaporin 4 (AQP4) functions as a water channel in the rat brain.

Detects ~35 kDa. May detect larger glycosylated bands ~50 kDa.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Physical form

PBS, pH 7..4, 50% glycerol, and 0.09% sodium azide

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Product No.

Description

Pricing

ZRB1254

Anti-Aquaporin-4 Antibody, clone 1K2 ZooMAb^® Rabbit Monoclonal, recombinant, expressed in HEK 293 cells

Storage Class

10 - Combustible liquids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number

1201

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Aquaporin 4 expression in human skeletal muscle fiber types.

Elisa Vizzaccaro et al.

Muscle & nerve, 57(5), 856-858 (2017-12-02)

Aquaporins (AQPs) are a family of transmembrane proteins involved in the maintenance of osmotic gradients. AQP4 is abundant in skeletal muscle, where it seems to be associated with glycolytic metabolism. We investigated the pattern of expression of AQP4 in normal

Increased expression of Aquaporin 4 in the rat hippocampus and cortex during trimethyltin-induced neurodegeneration.

S Ceccariglia et al.

Neuroscience, 274, 273-288 (2014-06-10)

Trimethyltin chloride (TMT) is a neurotoxicant producing neuronal degeneration and reactive astrogliosis in the mammalian central nervous system, especially the hippocampus. A previous magnetic resonance imaging investigation in TMT-treated rats evidenced dilation of lateral ventricles, also suggesting alterations in blood-brain

Anti-AQP4 autoantibodies promote ATP release from astrocytes and induce mechanical pain in rats.

Teruyuki Ishikura et al.

Journal of neuroinflammation, 18(1), 181-181 (2021-08-23)

Intractable neuropathic pain is a common symptom of neuromyelitis optica spectrum disorder (NMOSD). However, the underlying mechanism of NMOSD pain remains to be elucidated. In this study, we focused on ATP, which is one of the damage-associated molecular patterns, and

Aquaporin-4 reduces neuropathology in a mouse model of Alzheimer's disease by remodeling peri-plaque astrocyte structure.

Alex J Smith et al.

Acta neuropathologica communications, 7(1), 74-74 (2019-05-10)

Redistribution of the water channel aquaporin-4 (AQP4) away from astrocyte endfeet and into parenchymal processes is a striking histological feature in mouse models of Alzheimer's disease (AD) and other neurological conditions with prominent astrogliosis. AQP4 redistribution has been proposed to

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