SAB5300177

Anti-SOX2 Antibody

Name: Anti-SOX2 Antibody
Brand: SIGMA
Price: 580 USD

mouse monoclonal, 10F10

Synonym(s):

Sox-2, Sox2, lcc, ysb

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100 μL

$580.00

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A recombinant, preservative-free antibody is available for your target. Try ZRB5603

About This Item

UNSPSC Code:

12352203

NACRES:

NA.41

Key Documents

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Product Name

Monoclonal Anti-SOX2 antibody produced in mouse, clone 10F10, ascites fluid

biological source

mouse

conjugate

unconjugated

antibody form

ascites fluid

antibody product type

primary antibodies

clone

10F10, monoclonal

mol wt

34 kDa

species reactivity

human

technique(s)

direct ELISA: 1:10,000
immunohistochemistry: 1:200-1:1,000
indirect immunofluorescence: 1:200-1:1,000
western blot: 1:500-1:2,000

isotype

IgG1

UniProt accession no.

P48431

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Quality Level

100

Gene Information

human ... SOX2(20674)

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Show Differences

1 of 4

This Item	AMAB91307	AMAB91141	SAB1402364
Sigma-Aldrich SAB5300177 Monoclonal Anti-SOX2 antibody produced in mouse	Sigma-Aldrich AMAB91307 Monoclonal Anti-SOX2 antibody produced in mouse	Sigma-Aldrich AMAB91141 Monoclonal Anti-SSX2 antibody produced in mouse	Sigma-Aldrich SAB1402364 Monoclonal Anti-SSX2 antibody produced in mouse
antibody form ascites fluid	antibody form purified immunoglobulin	antibody form purified immunoglobulin	antibody form purified immunoglobulin
Gene Information human ... SOX2(20674)	Gene Information human ... SOX2(6657)	Gene Information human ... SSX2(6757)	Gene Information human ... SSX2(6757)
biological source mouse	biological source mouse	biological source mouse	biological source mouse
conjugate unconjugated	conjugate unconjugated	conjugate unconjugated	conjugate unconjugated
species reactivity human	species reactivity mouse, human	species reactivity human	species reactivity human
clone 10F10, monoclonal	clone CL4716, monoclonal	clone CL3202, monoclonal	clone 1A4, monoclonal

Application

Monoclonal Anti-SOX2 antibody has been used as a core pluripotency factor to regulate stem cell pluripotency.

Biochem/physiol Actions

SOX2 (sex-determining region Y-box 2) down-regulation reduces the stem cell count, that affects breast cancer cells in initiating tumor progression. It participates in chemoresistance and regular lung cancer therapies. In mouse, SOX2 plays an important role in branching morphogenesis and regulating lung epithelial cell differentiation.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

General description

SOX2 (sex-determining region Y-box 2) is a transcription factor consisting of 317 amino acids. It has an HMG (high mobility group box) domain and is a critical transcription regulator of normal stem cell. It is located on human chromosome 3q26.3.

Immunogen

Purified recombinant fragment of human SOX2 expressed in E.coli.
Mouse monoclonal antibody raised against SOX2

Physical form

Ascitic fluid containing 0.03% sodium azide.

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Storage Class

10 - Combustible liquids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number

PM12110682

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Generation of an iPSC cohort of isogenic iPSC lines (46-XY and 47-XXY) from a non-mosaic Klinefelter Syndrome patient (47-XXY) (KAUSTi008-A, KAUSTi008-B, KAUSTi008-C, KAUSTi008-D, KAUSTi008-E, KAUSTi008-F, KAUSTi008-G).

Elisabetta Fiacco et al.

Stem cell research, 50, 102119-102119 (2020-12-18)

Klinefelter Syndrome (KS) is the most common X chromosome aneuploidy in males characterized by highly heterogeneous clinical manifestations including a subtle cognitive impairment and multisystemic disorders such as infertility, metabolic syndrome, gynecomastia and cardiovascular diseases. To date dosage-dependent correlation studies of X-linked

Generation of two iPSC lines (KAUSTi001-A, KAUSTi002-A) from a rare high-grade Klinefelter Syndrome patient (49-XXXXY) carrying a balanced translocation t(4,11) (q35,q23).

Maryam Alowaysi et al.

Stem cell research, 49, 102098-102098 (2020-12-01)

Klinefelter Syndrome (KS) is the most common aneuploidy in humans (prevalence: 85-250 per 100,000 born males) and is characterized by one or more supernumerary X-chromosomes (47-XXY, 48-XXXY and 49-XXXXY karyotypes). KS is a multisystemic disorder associated to multiple phenotypic features

Derivation of two naturally isogenic iPSC lines (KAUSTi006-A and KAUSTi006-B) from a mosaic Klinefelter Syndrome patient (47-XXY/46-XY).

Elisabetta Fiacco et al.

Stem cell research, 49, 102049-102049 (2020-10-24)

While Klinefelter Syndrome (KS) has a prevalence of 85-250 per 100,000 born males, patients are typically underdiagnosed due to a subtle phenotype emerging only late during puberty or adulthood. Rare cases of KS carry a mosaic phenotype 47-XXY/46-XY associated to

Establishment of an iPSC cohort from three unrelated 47-XXY Klinefelter Syndrome patients (KAUSTi007-A, KAUSTi007-B, KAUSTi009-A, KAUSTi009-B, KAUSTi010-A, KAUSTi010-B).

Maryam Alowaysi et al.

Stem cell research, 49, 102042-102042 (2020-10-18)

Klinefelter Syndrome (KS) is caused by the presence of a supernumerary X chromosome. Cytogenetic studies revaled that 80-90% of patients carry a 47-XXY karyotype, while 10-20% of cases are represented by mosaic 46-XY/47-XXY and high-grade aneuploidies 48-XXXY and 48-XXYY. The phenotypic traits

Generation of iPSC lines (KAUSTi011-A, KAUSTi011-B) from a Saudi patient with epileptic encephalopathy carrying homozygous mutation in the GLP1R gene.

Maryam Alowaysi et al.

Stem cell research, 50, 102148-102148 (2021-01-10)

Glucagon-like peptide-1 receptor (GLP1R) is a seven-transmembrane-spanning helices membrane protein expressed in multiple human tissues including pancreatic islets, lung, brain, heart and central nervous system (CNS). GLP1R agonists are commonly used as antidiabetic drugs, but a neuroprotective function in neurodegenerative

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Anti-SOX2 Antibody

mouse monoclonal, 10F10

Select a Size

SAB5300177-100UL

$580.00

About This Item

Key Documents

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Properties

Product Name

biological source

conjugate

antibody form

antibody product type

clone

mol wt

species reactivity

technique(s)

isotype

UniProt accession no.

shipped in

storage temp.

target post-translational modification

Quality Level

Gene Information

Compare Similar Items

This Item

Description

Application

Biochem/physiol Actions

Disclaimer

General description

Immunogen

Physical form

Safety Information

Storage Class

wgk

flash_point_f

flash_point_c

Documentation

Certificates of Analysis (COA)

Already Own This Product?

Peer Reviewed Papers

Questions

Reviews

Active Filters

Technical Service